897 pneumococcal vaccine (pnvx) in sickle cell disease (scd): igg and igm antibody response

ABSTRACT The IgG and IgM class-specific antibody response to PnVx in SCD patients was investigated since pneumococcal infection after PnVx occurs in some SCD patients and since patients with

functional asplenia (including SCD) may not be able to form normal levels of protective antibody and/or switch from IgM to IgG class of antibody in response to certain antigens. Both

normals and SCD patients formed IgG as well as IgM antibody by ELISA to each pneumococcal type tested. The level and predominant class of antibody varied between serotypes. Mean

Fold-increase (log2) in Antibody Titer to PnVx Serotypes: Although statistically significant differences were not found, slightly lower responses were noted in SCD patients, especially to

type 6, a serotype frequently associated with PnVx failure. Further testing in patients with PnVx failure will be necessary to determine if inadequate IgG or IgM response contributes to lack

of protection In these instances. ARTICLE PDF AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Departments of Pediatrics, University of Florida, Gainesville, and University of California, San

Francisco Douglas J Barrett & Arthur J Ammann Authors * Douglas J Barrett View author publications You can also search for this author inPubMed Google Scholar * Arthur J Ammann View

author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Barrett, D., Ammann, A.

897 PNEUMOCOCCAL VACCINE (PnVx) IN SICKLE CELL DISEASE (SCD): IgG AND IgM ANTIBODY RESPONSE. _Pediatr Res_ 15 (Suppl 4), 592 (1981). https://doi.org/10.1203/00006450-198104001-00922 Download

citation * Issue Date: 01 April 1981 * DOI: https://doi.org/10.1203/00006450-198104001-00922 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content:

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