852 thrombocytosis in patients with sickle cell anemia and pneumonia

ABSTRACT Alterations in platelet function in patients with sickle cell anemia (SCA) may contribute to vaso-occlusive crises. Since thrombocytosis may further enhance thrombotic tendencies,

we investigated the occurrence rate, magnitude and adverse effects of thrombocytosis in children with SCA and pneumonia. In 37 patients, 47 episodes of pneumonia were evaluated. Platelet

counts in 7 patients rose to greater than 1 × 106/mm3 and in 16 patients to ≥750,000/mm3. The mean platelet count began to rise on the fifth day. From day 7 to day 21 the average platelet

count was greater than twice the average count on admission and during asymptomatic periods. There were no platelet aggregation abnormalities detected initially or after the development of

thrombocytosis. The mean platelet volumes, determined on an electronic particle counter, also remained constant. Only one patient had a painful crisis during the duration of post-pneumonia

thrombocytosis. His painful crisis resolved despite a continued rise in platelet count. Although thrombocytosis following pneumonia in patients with SCA is common, the risk of related

vaso-occlusive sequelae appears low and anti-platelet therapy does not appear warranted. ARTICLE PDF AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Pediatrics, University of

Pennsylvania School of Medicine and The Children's Hospital of Philadelphia, Philadelphia Mortimer Poncz, Jay Groenberg, Marie O Russell, Elias Schwartz & Alan R Cohen Authors *

Mortimer Poncz View author publications You can also search for this author inPubMed Google Scholar * Jay Groenberg View author publications You can also search for this author inPubMed 

Google Scholar * Marie O Russell View author publications You can also search for this author inPubMed Google Scholar * Elias Schwartz View author publications You can also search for this

author inPubMed Google Scholar * Alan R Cohen View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS

ARTICLE CITE THIS ARTICLE Poncz, M., Groenberg, J., Russell, M. _et al._ 852 THROMBOCYTOSIS IN PATIENTS WITH SICKLE CELL ANEMIA AND PNEUMONIA. _Pediatr Res_ 15 (Suppl 4), 584 (1981).

https://doi.org/10.1203/00006450-198104001-00877 Download citation * Issue Date: 01 April 1981 * DOI: https://doi.org/10.1203/00006450-198104001-00877 SHARE THIS ARTICLE Anyone you share the

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