830 treatment of recurrent laryngeal papillomatosis with an interferon inducer

ABSTRACT Papillomatosls is a potentially life-threatening proliferative lesion of the larynx; a viral etiology is postulated. Repeated recurrence can occur requiring frequent surgery for

maintenance of a patent airway. The synthetic interferon inducer polylnosinic-polycytidillc acid stabilized with poly-L-lysine (Poly ICLC) was used l.v. In 6 patients. Doses ranged from 2.5

mg/m2 to 12 mg/m2 t.i.w. for a three month course. In all patients a marked decrease in the requirement for surgery was seen. No regression of pulmonary lesions was seen in 3/3 patients with

such lesions. Toxiclty consisted of fever, nausea and headache; mild neutropenla lasting 1-3 days and transient transaminase elevations. Variable serum interferon titers ranging from

100-3000 units were seen 8 hours after each dose (peak titer). The dramatic decrease in the requirement for surgery in these patients suggests that additional studies of antiviral agents in

papillomatous diseases are indicated. Supported in part by General Clinical Research Center-Pediatrics grant RR-0052 and General Research grant RR-0046. ARTICLE PDF AUTHOR INFORMATION

AUTHORS AND AFFILIATIONS * Johns Hopkins University, University of North Carollna, National Cancer Institute & National Institute of Allergy & Infectious Diseases, National

Institutes of Health, Brigid Leventhal, John Whlsnan, Hasklns Kashima, Arthur Levine & Hilton Levy Authors * Brigid Leventhal View author publications You can also search for this author

inPubMed Google Scholar * John Whlsnan View author publications You can also search for this author inPubMed Google Scholar * Hasklns Kashima View author publications You can also search

for this author inPubMed Google Scholar * Arthur Levine View author publications You can also search for this author inPubMed Google Scholar * Hilton Levy View author publications You can

also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Leventhal, B., Whlsnan, J., Kashima, H. _et al._ 830

TREATMENT OF RECURRENT LARYNGEAL PAPILLOMATOSIS WITH AN INTERFERON INDUCER. _Pediatr Res_ 15 (Suppl 4), 581 (1981). https://doi.org/10.1203/00006450-198104001-00855 Download citation * Issue

Date: 01 April 1981 * DOI: https://doi.org/10.1203/00006450-198104001-00855 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link

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