824 the varying clinical spectrum of presentation of burkitt's lymphoma in children

ABSTRACT Burkitt's lymphoma is a rare neoplasm in children and has varied clinical presentations and course. Six Caucasion children between the ages of 5 and 18 years were studied at

Henry Ford Hospital. Five were male and one was female. Five out of six of the patients were initially diagnosed as having gastroenteritis. Their initial presentation was abdominal pain,

vomiting and distention. Two of the children had evidence of acute intestinal obstruction at the time of diagnosis. Leukemic transformation (4/6), meningeal involvement (3/6), testicular

involvement (1/6), bilateral ovarian involvement with ascites and hypomenorrhea (1/6), monarticular arthritis with bone involvement (1/6), massive pleural effusion (1/6), submandibular

lymphadenopathy (1/6) were other clinical signs present at the time of diagnosis. Two out of six achieved complete remission on chemotherapy and are long-term survivors at 70 months and 66

months. Serum lactic dehydrogenase (LDH) levels closely correlated with recurrence and extent of tumor mass. Both patients who had complete remissions had only localized disease and had LDH

levels below 400 IU/cc. Metabolic complications encountered consisted of uric acid nephropathy (1), hypocalcemia and hyperphosphatemia (2) with uncontrolled seizures. Morphological,

cytochemical and ultrastructural studies were performed to confirm the pathological diagnosis. ARTICLE PDF AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Pediatrics, Spon. by L.

Weiss. Henry Ford Hospital, Detroit, Michigan K R Kini, S Raman, R P Warrler, E Abdulkadir, M Poel & A Shringeri Authors * K R Kini View author publications You can also search for this

author inPubMed Google Scholar * S Raman View author publications You can also search for this author inPubMed Google Scholar * R P Warrler View author publications You can also search for

this author inPubMed Google Scholar * E Abdulkadir View author publications You can also search for this author inPubMed Google Scholar * M Poel View author publications You can also search

for this author inPubMed Google Scholar * A Shringeri View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions

ABOUT THIS ARTICLE CITE THIS ARTICLE Kini, K., Raman, S., Warrler, R. _et al._ 824 THE VARYING CLINICAL SPECTRUM OF PRESENTATION OF BURKITT'S LYMPHOMA IN CHILDREN. _Pediatr Res_ 15

(Suppl 4), 580 (1981). https://doi.org/10.1203/00006450-198104001-00849 Download citation * Issue Date: 01 April 1981 * DOI: https://doi.org/10.1203/00006450-198104001-00849 SHARE THIS

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