Plasma renin activity (pra) in the assessment of persistent hypertension (ht) of renal allograft recipients

ABSTRACT To differentiate medically treatable causes of hypertension from those requiring surgical intervention, 9 renal transplant recipients (aged 15-19 yrs) fulfilling the following

criteria were investigated: a) at least 3 months after transplantation, b) original diseased kidneys removed, c) no evidence of rejection d) steroid dosage at low levels. According to

sitting diastolic BP and response to antihypertensive drugs the patients were divided into 3 groups (I) severe, (II) moderate and (III) no HT (3 patients in each). All patients in groups I

and II demonstrated allograft renal artery stenosis (RAS) by arteriography, the % luminal occlusion being more pronounced in the group I ( >50%). The excessive peripheral PRA easily

distinguished the group with unmistakably severe RAS from the others. After a diuretic the differences were even more exaggerated. The bromide space was reduced in 6/9 patients, mean 93.8%,

when compared to normals by Cheek. Allograft RAS did not act like a single kidney Goldblatt model. PRA can help select those post-transplant HT patients who require arteriography and

subsequent surgery. ARTICLE PDF AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * The Hospital for Sick Children, Toronto, Ontario A Hsu, J Balfe, P Olley, B Kidd, G Arbus, B Churchill & 

Donald Fraser Authors * A Hsu View author publications You can also search for this author inPubMed Google Scholar * J Balfe View author publications You can also search for this author

inPubMed Google Scholar * P Olley View author publications You can also search for this author inPubMed Google Scholar * B Kidd View author publications You can also search for this author

inPubMed Google Scholar * G Arbus View author publications You can also search for this author inPubMed Google Scholar * B Churchill View author publications You can also search for this

author inPubMed Google Scholar * Donald Fraser View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS

ARTICLE CITE THIS ARTICLE Hsu, A., Balfe, J., Olley, P. _et al._ PLASMA RENIN ACTIVITY (PRA) IN THE ASSESSMENT OF PERSISTENT HYPERTENSION (HT) OF RENAL ALLOGRAFT RECIPIENTS. _Pediatr Res_

11, 552 (1977). https://doi.org/10.1203/00006450-197704000-01091 Download citation * Issue Date: 01 April 1977 * DOI: https://doi.org/10.1203/00006450-197704000-01091 SHARE THIS ARTICLE

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