Genomic drivers of resistance to ar therapies

Access through your institution Buy or subscribe Researchers in Canada have identified genomic drivers of resistance to androgen-receptor (AR)-directed therapies in men with metastatic

castration-resistant prostate cancer (mCRPC). Annala _ et al_. performed whole-exome and/or deep targeted sequencing of plasma-derived cell-free DNA samples from 202 treatment-naive men with

mCRPC randomly assigned to abiraterone or enzalutamide. Defects in _BRCA2_ and _ATM_ were associated with poor clinical outcomes independently of clinical prognostic factors and abundance

of circulating tumour DNA. Deleterious alterations in _TP53_ were also associated with reduced time to progression. This is a preview of subscription content, access via your institution

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FAQs * Contact customer support REFERENCES * Annala, M. _ et al_. Circulating tumor DNA genomics correlate with resistance to abiraterone and enzalutamide in prostate cancer. _Cancer

Discov._ https://doi.org/10.1158/2159-8290.CD-17-0937 (2018) Article  CAS  Google Scholar  Download references Authors * Rebecca Kelsey View author publications You can also search for this

author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Kelsey, R. Genomic drivers of resistance to AR therapies. _Nat Rev Urol_

15, 202 (2018). https://doi.org/10.1038/nrurol.2018.18 Download citation * Published: 13 February 2018 * Issue Date: April 2018 * DOI: https://doi.org/10.1038/nrurol.2018.18 SHARE THIS

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