Novel subtyping could aid stratification and therapy

Access through your institution Buy or subscribe New results show that RNA expression data can be used to categorize prostate cancer into three distinct molecular subtypes that can be used

to detect aggressive tumours and improve diagnostics. You _ et al_. mapped pathway activation gene expression signatures into three categories: prostate-cancer-relevant signalling pathways,

genetic and genomic alterations, and biological features related to aggressive prostate cancer progression. Pathway activation scores were then computed in each specimen in the DISC cohort

(_n_ = 1,321). Using these pathway activation profiles, a consensus map of non-negative matrix factorization (NMF) clustering showed that the samples could be split into three groups that

correspond to three subtypes: PCS1, PCS2, and PCS3. PCS1 displayed high activation scores for EZH2, PTEN, PRF, ES, AV and AR-V pathways. PCS2 was characterized by ERG pathway activation, as

well as AR, FOXA1, and SPOP. By comparison, PCS3 showed high activation of RAS, PN, and MES, but low activation of AR and AR-V pathways. Validation using a 14-pathway classifier was able to

accurately classify tumours in the DISC cohort into these three subtypes. This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through your

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to full article PDF Buy now Prices may be subject to local taxes which are calculated during checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read

our FAQs * Contact customer support REFERENCES * You, S. _ et al_. Integrated classification of prostate cancer reveals a novel luminal subtype with poor outcome. _Cancer Res._

http://dx.doi.org/10.1158/0008-5472.CAN-16-0902 (2016) Download references Authors * Annette Fenner View author publications You can also search for this author inPubMed Google Scholar

RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Fenner, A. Novel subtyping could aid stratification and therapy. _Nat Rev Urol_ 13, 435 (2016).

https://doi.org/10.1038/nrurol.2016.130 Download citation * Published: 05 July 2016 * Issue Date: August 2016 * DOI: https://doi.org/10.1038/nrurol.2016.130 SHARE THIS ARTICLE Anyone you

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