TGF-β signalling regulator PMEPA1 halts metastases to bone
TGF-β signalling regulator PMEPA1 halts metastases to bone"
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New research, published in Cancer Cell, has shown that PMEPA1 inhibits TGF-β signalling by a nonproteasomal mechanism and that knockdown of PMAPA1 increases prometastatic gene expression and
bone metastases in a mouse model.
TGF-β is a critical regulator of cell proliferation and differentiation and that it has a complex role is cancer is well known. Fournier and colleagues sort to characterize the role of TGF-β
signalling and regulated genes in the development of bone metastases in prostate cancer.
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