Tgf-β signalling regulator pmepa1 halts metastases to bone

Access through your institution Buy or subscribe New research, published in _Cancer Cell_, has shown that PMEPA1 inhibits TGF-β signalling by a nonproteasomal mechanism and that knockdown of

PMAPA1 increases prometastatic gene expression and bone metastases in a mouse model. TGF-β is a critical regulator of cell proliferation and differentiation and that it has a complex role

is cancer is well known. Fournier and colleagues sort to characterize the role of TGF-β signalling and regulated genes in the development of bone metastases in prostate cancer. This is a

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during checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support REFERENCES * Fournier, P. G. J. _ et al_. The TGF-β

signalling regulator PMEPA1 suppresses prostate cancer to bone. _Cancer Cell_ 10.1016/j.ccell.2015.04.009 Download references Authors * Louise Stone View author publications You can also

search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Stone, L. TGF-β signalling regulator PMEPA1 halts

metastases to bone. _Nat Rev Urol_ 12, 362 (2015). https://doi.org/10.1038/nrurol.2015.136 Download citation * Published: 09 June 2015 * Issue Date: July 2015 * DOI:

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