Long-term use of nonaspirin nsaids increases rcc risk

Access through your institution Buy or subscribe Analgesic medications are widely used, with aspirin, acetominophen and ibuprofen representing the three most commonly used prescription and

over-the-counter drugs. In fact, a US national survey showed that nearly 30% of participants aged 57–85 years take aspirin. However, these drugs also have effects on other systems—for

example, the well-documented protective effect of aspirin in cardiovascular disease, and the anticancer effect of aspirin and other NSAIDs, which is thought to be mediated by cyclooxygenase

2 inhibition, reduced inflammation and effects on cell proliferation and apoptosis. Contrary to this hypothesis though, is the suggestion that analgesic use may actually be associated with

an increased risk of cancer. This association has previously been investigated using case-control studies, but a team from the USA has now carried out two large prospective studies to

examine the use of analgesics with regard to risk of renal cell carcinoma (RCC). The results were published in _Archives of Internal Medicine_. This is a preview of subscription content,

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OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support ORIGINAL RESEARCH PAPER * Cho, E. _ et al_. Prospective evaluation of analgesic use and

risk of renal call cancer. _Arch. Intern. Med._ 171, 1487–1493 (2011) Article  PubMed  PubMed Central  Google Scholar  Download references Authors * Annette Fenner View author publications

You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Fenner, A. Long-term use of nonaspirin NSAIDs

increases RCC risk. _Nat Rev Urol_ 8, 590 (2011). https://doi.org/10.1038/nrurol.2011.148 Download citation * Published: 04 October 2011 * Issue Date: November 2011 * DOI:

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