In brief | Nature Reviews Urology

Access through your institution Buy or subscribe New research in rodents has shown that antagonizing the ligand-gated cation channel TRPV1 increases the threshold for activation of the

micturition reflex. The research team found this effect to be mediated by capsaicin-sensitive pathways. In animals with detrusor overactivity induced by capsaicin or citric acid,

administration of TRPV1 blockers prevented lowering of the micturition threshold volume and reduction of voiding interval. Cefalu, J. S. _ et al_. Selective pharmacological blockade of the

TRPV1 receptor suppresses sensory reflexes of the rodent bladder. _J. Urol._ 182, 776–785 (2009). This is a preview of subscription content, access via your institution ACCESS OPTIONS Access

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subscriptions * Read our FAQs * Contact customer support RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE In brief . _Nat Rev Urol_ 6, 467 (2009).

https://doi.org/10.1038/nrurol.2009.165 Download citation * Issue Date: September 2009 * DOI: https://doi.org/10.1038/nrurol.2009.165 SHARE THIS ARTICLE Anyone you share the following link

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