Connectivity to other fields brings new ideas

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Connectivity to other fields brings new ideas"


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Multiple scientific fields pertaining to inflammation, including the fields of cardiovascular, infection and cancer research, are increasingly contributing to our understanding of rheumatoid


arthritis (RA). In 2017, such research has helped develop our understanding of RA comorbidity, the link between RA pathogenesis and infection, and the effects of new therapies. Access


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are calculated during checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support REFERENCES * Ridker, P. M. _ et al_.


Antiinflammatory therapy with canakinumab for atherosclerotic disease. _N. Engl. J. Med._ 377, 1119–1131 (2017). Article  CAS  Google Scholar  * Dutzan, N. _ et al_. On-going mechanical


damage from mastication drives homeostatic Th17 cell responses at the oral barrier. _Immunity_ 46, 133–147 (2017). Article  CAS  Google Scholar  * Belkhir, R. _ et al_. Rheumatoid arthritis


and polymyalgia rheumatica occurring after immune checkpoint inhibitor treatment. _Ann. Rheum. Dis._ 76, 1747–1750 (2017). Article  CAS  Google Scholar  * Hong, S. S. _ et al_. _PUMA_ gene


delivery to synoviocytes reduces inflammation and degeneration of arthritic joints. _Nat. Commun._ 8, 146 (2017). Article  Google Scholar  * Robertson, J. _ et al_. Interleukin-6 blockade


raises LDL via reduced catabolism rather than via increased synthesis: a cytokine-specific mechanism for cholesterol changes in rheumatoid arthritis. _Ann. Rheum. Dis._ 76, 1949–1952 (2017).


Article  CAS  Google Scholar  * Hot, A., Lavocat, F., Lenief, V. & Miossec, P. Simvastatin inhibits the pro-inflammatory and pro-thrombotic effects of IL-17 and TNF-α on endothelial


cells. _Ann. Rheum. Dis._ 72, 754–760 (2013). Article  CAS  Google Scholar  * Miossec, P., Cavender, D. & Ziff, M. Production of interleukin 1 by human endothelial cells. _J. Immunol._


136, 2486–2491 (1986). CAS  PubMed  Google Scholar  * Ridker, P. M. _ et al_. Effect of interleukin-1β inhibition with canakinumab on incident lung cancer in patients with atherosclerosis:


exploratory results from a randomised, double-blind, placebo-controlled trial. _Lancet_ 390, 1833–1842 (2017). Article  CAS  Google Scholar  * Pfeifle, R. _ et al_. Regulation of


autoantibody activity by the IL-23-TH17 axis determines the onset of autoimmune disease. _Nat. Immunol._ 18, 104–113 (2017). Article  CAS  Google Scholar  * Yamanishi, Y. _ et al_. Regional


analysis of _p53_ mutations in rheumatoid arthritis synovium. _Proc. Natl Acad. Sci. USA_ 99, 10025–10030 (2002). Article  CAS  Google Scholar  Download references ACKNOWLEDGEMENTS The work


of the author has been supported by the OpeRa IHU programme and the Institut Universitaire de France. P.M. is a senior member of the Institut Universitaire de France. AUTHOR INFORMATION


AUTHORS AND AFFILIATIONS * Department of Clinical Immunology and Rheumatology, University of Lyon, 5 Place d'Arsonval, Lyon, 69437, France Pierre Miossec Authors * Pierre Miossec View


author publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to Pierre Miossec. ETHICS DECLARATIONS COMPETING INTERESTS The author


declares no competing financial interests. POWERPOINT SLIDES POWERPOINT SLIDE FOR FIG. 1 RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Miossec, P.


Connectivity to other fields brings new ideas. _Nat Rev Rheumatol_ 14, 65–66 (2018). https://doi.org/10.1038/nrrheum.2017.215 Download citation * Published: 11 January 2018 * Issue Date:


February 2018 * DOI: https://doi.org/10.1038/nrrheum.2017.215 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a


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