Connectivity to other fields brings new ideas
Connectivity to other fields brings new ideas"
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Multiple scientific fields pertaining to inflammation, including the fields of cardiovascular, infection and cancer research, are increasingly contributing to our understanding of rheumatoid
arthritis (RA). In 2017, such research has helped develop our understanding of RA comorbidity, the link between RA pathogenesis and infection, and the effects of new therapies. Access
through your institution Buy or subscribe This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through your institution Access Nature and 54 other
Nature Portfolio journals Get Nature+, our best-value online-access subscription $29.99 / 30 days cancel any time Learn more Subscribe to this journal Receive 12 print issues and online
access $209.00 per year only $17.42 per issue Learn more Buy this article * Purchase on SpringerLink * Instant access to full article PDF Buy now Prices may be subject to local taxes which
are calculated during checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support REFERENCES * Ridker, P. M. _ et al_.
Antiinflammatory therapy with canakinumab for atherosclerotic disease. _N. Engl. J. Med._ 377, 1119–1131 (2017). Article CAS Google Scholar * Dutzan, N. _ et al_. On-going mechanical
damage from mastication drives homeostatic Th17 cell responses at the oral barrier. _Immunity_ 46, 133–147 (2017). Article CAS Google Scholar * Belkhir, R. _ et al_. Rheumatoid arthritis
and polymyalgia rheumatica occurring after immune checkpoint inhibitor treatment. _Ann. Rheum. Dis._ 76, 1747–1750 (2017). Article CAS Google Scholar * Hong, S. S. _ et al_. _PUMA_ gene
delivery to synoviocytes reduces inflammation and degeneration of arthritic joints. _Nat. Commun._ 8, 146 (2017). Article Google Scholar * Robertson, J. _ et al_. Interleukin-6 blockade
raises LDL via reduced catabolism rather than via increased synthesis: a cytokine-specific mechanism for cholesterol changes in rheumatoid arthritis. _Ann. Rheum. Dis._ 76, 1949–1952 (2017).
Article CAS Google Scholar * Hot, A., Lavocat, F., Lenief, V. & Miossec, P. Simvastatin inhibits the pro-inflammatory and pro-thrombotic effects of IL-17 and TNF-α on endothelial
cells. _Ann. Rheum. Dis._ 72, 754–760 (2013). Article CAS Google Scholar * Miossec, P., Cavender, D. & Ziff, M. Production of interleukin 1 by human endothelial cells. _J. Immunol._
136, 2486–2491 (1986). CAS PubMed Google Scholar * Ridker, P. M. _ et al_. Effect of interleukin-1β inhibition with canakinumab on incident lung cancer in patients with atherosclerosis:
exploratory results from a randomised, double-blind, placebo-controlled trial. _Lancet_ 390, 1833–1842 (2017). Article CAS Google Scholar * Pfeifle, R. _ et al_. Regulation of
autoantibody activity by the IL-23-TH17 axis determines the onset of autoimmune disease. _Nat. Immunol._ 18, 104–113 (2017). Article CAS Google Scholar * Yamanishi, Y. _ et al_. Regional
analysis of _p53_ mutations in rheumatoid arthritis synovium. _Proc. Natl Acad. Sci. USA_ 99, 10025–10030 (2002). Article CAS Google Scholar Download references ACKNOWLEDGEMENTS The work
of the author has been supported by the OpeRa IHU programme and the Institut Universitaire de France. P.M. is a senior member of the Institut Universitaire de France. AUTHOR INFORMATION
AUTHORS AND AFFILIATIONS * Department of Clinical Immunology and Rheumatology, University of Lyon, 5 Place d'Arsonval, Lyon, 69437, France Pierre Miossec Authors * Pierre Miossec View
author publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to Pierre Miossec. ETHICS DECLARATIONS COMPETING INTERESTS The author
declares no competing financial interests. POWERPOINT SLIDES POWERPOINT SLIDE FOR FIG. 1 RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Miossec, P.
Connectivity to other fields brings new ideas. _Nat Rev Rheumatol_ 14, 65–66 (2018). https://doi.org/10.1038/nrrheum.2017.215 Download citation * Published: 11 January 2018 * Issue Date:
February 2018 * DOI: https://doi.org/10.1038/nrrheum.2017.215 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a
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