New insights into therapy—tnf blockade and beyond

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New insights into therapy—tnf blockade and beyond"


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Novel findings shed light on the role of tumor necrosis factor in ankylosis and inflammation, pointing to new indications for blockade of this cytokine in treating spondyloarthritis. At the


same time, the identification of other potential targets for therapy could expand the treatment options for this family of inflammatory disorders. Access through your institution Buy or


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are calculated during checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support REFERENCES * Rudwaleit, M. _ et al_.


The development of Assessment of SpondyloArthritis International Society classification criteria for axial spondyloarthritis (part II): validation and final selection. _Ann. Rheum. Dis._ 68,


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spondyloarthritis and for spondyloarthritis in general. _Ann. Rheum. Dis._ 70, 25–31 (2011). Article  CAS  Google Scholar  * Rudwaleit, M., Khan, M. A. & Sieper, J. The challenge of


diagnosis and classification in early ankylosing spondylitis: do we need new criteria? _Arthritis Rheum._ 52, 1000–1008 (2005). Article  Google Scholar  * van der Heijde, D. _ et al_.


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multicenter, double-blind, placebo-controlled trial of etanercept in adults with refractory heel enthesitis in spondyloarthritis: the HEEL trial. _Ann. Rheum. Dis._ 69, 1430–1435 (2010).


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_Arthritis Rheum._ 62, 1298–1307 (2010). Article  CAS  Google Scholar  Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Medicine, Rheumatology, Charité Campus


Benjamin Franklin, Hindenburgdamm 30, Berlin, 12200, Germany Joachim Sieper Authors * Joachim Sieper View author publications You can also search for this author inPubMed Google Scholar


ETHICS DECLARATIONS COMPETING INTERESTS J. Sieper has acted as a consultant for and has received grant support and/or honoraria from Abbott, Merck and Pfizer. RIGHTS AND PERMISSIONS Reprints


and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Sieper, J. New insights into therapy—TNF blockade and beyond. _Nat Rev Rheumatol_ 7, 78–80 (2011).


https://doi.org/10.1038/nrrheum.2010.224 Download citation * Published: 02 February 2011 * Issue Date: February 2011 * DOI: https://doi.org/10.1038/nrrheum.2010.224 SHARE THIS ARTICLE Anyone


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