Novel microrna expressed in osteoblasts promotes bone formation

Access through your institution Buy or subscribe In a study published in _The Journal of Clinical Investigation_, Li _ et al_. demonstrated in ST2 stromal cells that miR-2861 promotes

osteogenic differentiation induced by bone morphogenetic protein 2 (BMP2). Overexpression of miR-2861 increased levels of AMP activity, osteocalcin secretion, and bone nodule formation in

cultures. In addition, expression of runt-related transcription factor 2 (RUNX2) protein, but not _Runx2_ messenger RNA (mRNA), was increased in miR-2861-transfected cells compared with

control cells. In contrast to these effects, silencing expression of miR-2861 attenuated BMP2-induced osteoblastogenesis. The investigators identified HDAC5, which is involved in RUNX2

degradation, as the most important target of miR-2861. Overexpression of miR-2861 decreased levels of HDAC5 protein but not _Hdac5_ mRNA, indicating that the effects of miR-2861 on

osteoblastogenesis occur at the post-translational level. This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through your institution Subscribe to

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support ORIGINAL RESEARCH PAPERS * Li, H. _ et al_. A novel microRNA targeting HDAC5 regulates osteoblast differentiation in mice and contributes to primary osteoporosis in humans. _J.

Clin. Invest._ 119, 3666–3677 (2009) Article  CAS  Google Scholar  Download references Authors * Sarah Price View author publications You can also search for this author inPubMed Google

Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Price, S. Novel microRNA expressed in osteoblasts promotes bone formation. _Nat Rev Rheumatol_ 6,

64 (2010). https://doi.org/10.1038/nrrheum.2009.268 Download citation * Issue Date: February 2010 * DOI: https://doi.org/10.1038/nrrheum.2009.268 SHARE THIS ARTICLE Anyone you share the

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