Targeting cathepsin k to prevent cartilage loss: evidence from a dog model of oa

Access through your institution Buy or subscribe Connor, J. R. _ et al_. Protective effects of a cathepsin K inhibitor, SB-553484, in the canine partial medial meniscectomy model of

osteoarthritis. _Osteoarthritis Cartilage_ doi:10.1016/j.joca.2009.03.015 New research suggests that blocking the activity of cathepsin K could prevent the structural damage associated with

osteoarthritis (OA), a condition for which no disease-modifying therapies are currently available. The mild-to-moderate beneficial effects of treatment observed in the canine partial medial

meniscectomy model of the disease suggest that “inhibition of cathepsin K may represent a valid therapeutic strategy for treatment of OA,” say the study's lead investigators, Janice

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Targeting cathepsin K to prevent cartilage loss: evidence from a dog model of OA. _Nat Rev Rheumatol_ 5, 411 (2009). https://doi.org/10.1038/nrrheum.2009.113 Download citation * Issue Date:

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