Could antibodies cause psychosis?

Access through your institution Buy or subscribe Antibodies against neuronal cell surface receptors are more common among patients with psychosis, according to new research, suggesting that

psychosis could be antibody-mediated. The finding raises the possibility of treating some cases of psychosis with immunotherapy. Psychosis is a common presenting symptom of

autoantibody-mediated encephalitis, which most commonly involves antibodies against the _N_-methyl-D-aspartate (NMDA) receptor. This observation has generated interest in whether the

autoantibodies are responsible for the psychosis, and whether psychosis that is not associated with encephalitis could be mediated by the same antibodies. This is a preview of subscription

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ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support REFERENCES * Lennox, B. R. _ et al_. Prevalence and clinical characteristics of

serum neuronal cell surface antibodies in first-episode psychosis: a case–control study. _Lancet Psychiatry_ http://dx.doi.org/10.1016/S2215-0366(16)30375-3 (2016) Download references

Authors * Ian Fyfe View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE

Fyfe, I. Could antibodies cause psychosis?. _Nat Rev Neurol_ 13, 67 (2017). https://doi.org/10.1038/nrneurol.2016.198 Download citation * Published: 23 December 2016 * Issue Date: February

2017 * DOI: https://doi.org/10.1038/nrneurol.2016.198 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a shareable

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