Bin1 variant increases risk of alzheimer disease through tau

Access through your institution Buy or subscribe A locus upstream of the gene _BIN1_ is second only to the apolipoprotein E locus as a genetic determinant of Alzheimer disease (AD)

susceptibility, but the underlying mechanism has been unclear. Now, Jean-Charles Lambert and coworkers have identified an insertion allele upstream of _BIN1_ that increases expression of

this gene and seems to be involved in the tau pathway of AD pathology. BIN1 is involved in numerous cellular processes, including endocytosis and regulation of cytoskeletal dynamics. “To

begin to lift the veil from the role of BIN1 in AD, we adopted a multidisciplinary approach including molecular and functional genetics, cell biology, neuropathology and _Drosophila_

biology,” says Lambert. This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through your institution Subscribe to this journal Receive 12 print

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PAPER * Chapuis, J. _ et al_. Increased expression of BIN1 mediates Alzheimer genetic risk by modulating tau pathology. _Mol. Psychiatry_ doi:10.1038/mp.2013.1 Article  CAS  Google Scholar 

Download references Authors * Katie Kingwell View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS

ARTICLE CITE THIS ARTICLE Kingwell, K. _BIN1_ variant increases risk of Alzheimer disease through tau. _Nat Rev Neurol_ 9, 184 (2013). https://doi.org/10.1038/nrneurol.2013.34 Download

citation * Published: 05 March 2013 * Issue Date: April 2013 * DOI: https://doi.org/10.1038/nrneurol.2013.34 SHARE THIS ARTICLE Anyone you share the following link with will be able to read

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