Albuminuria inhibits podocyte regeneration

Access through your institution Buy or subscribe Previous studies by Romagnani and colleagues, and by other groups, have shown that RPCs in the Bowman capsule can differentiate into

podocytes and could potentially replace them after injury. In the current study, Romagnani and colleagues used primary cultures of human RPCs and various strains of transgenic mice treated

with adriamycin (as a model of human focal segmental glomerulosclerosis [FSGS]) to investigate their hypothesis that proteinuria might contribute to the progression of glomerulosclerosis by

suppressing this regeneration. The researchers found that exposure of human RPCs to transferrin and IgG reduced their viability, whereas exposure to human serum albumin inhibited their

differentiation into podocytes by sequestering retinoic acid and preventing the retinoic-acid-response element (RARE)-mediated transcription of podocyte-specific genes. In transgenic mice

with adriamycin-induced nephropathy, blockade of retinoic acid synthesis increased proteinuria, inhibited RARE activation in RPCs and their differentiation into podocytes, and reduced

podocyte number, resulting in worsening of glomerulosclerosis. In contrast, treatment with retinoic acid reversed albuminuria-induced inhibition of RARE in RPCs, resulting in an increase in

their differentiation into podocytes, an increase in podocyte number, and a decrease in proteinuria. This is a preview of subscription content, access via your institution ACCESS OPTIONS

Access through your institution Subscribe to this journal Receive 12 print issues and online access $209.00 per year only $17.42 per issue Learn more Buy this article * Purchase on

SpringerLink * Instant access to full article PDF Buy now Prices may be subject to local taxes which are calculated during checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn about

institutional subscriptions * Read our FAQs * Contact customer support ORIGINAL RESEARCH PAPER * Peired, A. _ et al_. Proteinuria impairs podocyte regeneration by sequestering retinoic acid.

_J. Am. Soc. Nephrol._ doi:10.1681/ASN.2012090950 Download references Authors * Ellen F. Carney View author publications You can also search for this author inPubMed Google Scholar RIGHTS

AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Carney, E. Albuminuria inhibits podocyte regeneration. _Nat Rev Nephrol_ 9, 554 (2013).

https://doi.org/10.1038/nrneph.2013.159 Download citation * Published: 03 September 2013 * Issue Date: October 2013 * DOI: https://doi.org/10.1038/nrneph.2013.159 SHARE THIS ARTICLE Anyone

you share the following link with will be able to read this content: Get shareable link Sorry, a shareable link is not currently available for this article. Copy to clipboard Provided by the

Springer Nature SharedIt content-sharing initiative