Neurotrophic memory | Nature Reviews Neuroscience

Access through your institution Buy or subscribe G protein-coupled oestrogen receptor 1 (GPER1) is expressed in hippocampal dendritic spines and axon terminals, but its role in long-term

depression (LTD) is not known. Here, 17β-estradiol (E2) activation of GPER1 in CA3 resulted in the release of brain-derived neurotrophic factor and the local translation of

activity-regulated cytoskeleton-associated protein (ARC). This increase in ARC levels led to the internalization and proteasome-mediated degradation of GluA1-containing AMPA receptors, and

LTD, thus revealing a novel way in which E2 can mediate synaptic plasticity in the hippocampus. This is a preview of subscription content, access via your institution ACCESS OPTIONS Access

through your institution Subscribe to this journal Receive 12 print issues and online access $189.00 per year only $15.75 per issue Learn more Buy this article * Purchase on SpringerLink *

Instant access to full article PDF Buy now Prices may be subject to local taxes which are calculated during checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional

subscriptions * Read our FAQs * Contact customer support REFERENCES * Briz, V. et al. A novel form of synaptic plasticity in field CA3 of hippocampus requires GPER1 activation and BDNF

release. _J. Cell Biol._ 210, 1225–1237 (2015) Article  CAS  PubMed  PubMed Central  Google Scholar  Download references Authors * Sian Lewis View author publications You can also search for

this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Lewis, S. Neurotrophic memory. _Nat Rev Neurosci_ 16, 646 (2015).

https://doi.org/10.1038/nrn4049 Download citation * Published: 20 October 2015 * Issue Date: November 2015 * DOI: https://doi.org/10.1038/nrn4049 SHARE THIS ARTICLE Anyone you share the

following link with will be able to read this content: Get shareable link Sorry, a shareable link is not currently available for this article. Copy to clipboard Provided by the Springer

Nature SharedIt content-sharing initiative