Schwann cells keep axons healthy

Access through your institution Buy or subscribe Charcot-Marie-Tooth disease 1A (CMT1A) is an inherited neuropathy caused by duplication of the gene encoding peripheral myelin protein 22

(PMP22). In this study, _PMP22_ duplication in rodents caused defects in Schwann cell differentiation in early postnatal development, which persisted into adulthood. This abnormal Schwann

cell phenotype could be rescued by axonal overexpression of neuregulin-1 (NRG1) or by treatment with soluble NRG1 in early postnatal stages. These data suggest that there is a temporal

window for correct Schwann cell differentiation that is vital to prevent the neuropathy observed in CMT1A. This is a preview of subscription content, access via your institution ACCESS

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institutional subscriptions * Read our FAQs * Contact customer support REFERENCES * Fledrich, R. et al. Soluble neuregulin-1 modulates disease pathogenesis in rodent models of

Charcot-Marie-Tooth disease 1A. _Nature Med._ http://dx.doi.org/10.1038/nm.3664 (2014) Download references Authors * Sian Lewis View author publications You can also search for this author

inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Lewis, S. Schwann cells keep axons healthy. _Nat Rev Neurosci_ 15, 632 (2014).

https://doi.org/10.1038/nrn3831 Download citation * Published: 19 September 2014 * Issue Date: October 2014 * DOI: https://doi.org/10.1038/nrn3831 SHARE THIS ARTICLE Anyone you share the

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