Early trauma alters sperm RNA | Nature Reviews Neuroscience

Access through your institution Buy or subscribe The effects of traumatic early life experiences on adult behaviour can be transmitted to the next generation through unknown mechanisms. The

authors show that male mice exposed to early life stress exhibit altered behavioural responses, as do their offspring. The sperm of the traumatized mice exhibited changes in the levels of

small non-coding RNAs. Injection of RNAs purified from this sperm into wild-type oocytes produced offspring with behavioural alterations similar to those observed in traumatized mice,

indicating that sperm RNAs contribute to the transgenerational inheritance of the effects of early life trauma. This is a preview of subscription content, access via your institution ACCESS

OPTIONS Access through your institution Subscribe to this journal Receive 12 print issues and online access $189.00 per year only $15.75 per issue Learn more Buy this article * Purchase on

SpringerLink * Instant access to full article PDF Buy now Prices may be subject to local taxes which are calculated during checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn about

institutional subscriptions * Read our FAQs * Contact customer support REFERENCES * Gapp, K. et al. Implication of sperm RNAs in transgenerational inheritance of the effects of early trauma

in mice. _Nature Neurosci._ http://dx.doi.org/10.1038/nn.3695 (2014) Download references Authors * Katherine Whalley View author publications You can also search for this author inPubMed 

Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Whalley, K. Early trauma alters sperm RNA. _Nat Rev Neurosci_ 15, 349 (2014).

https://doi.org/10.1038/nrn3750 Download citation * Published: 30 April 2014 * Issue Date: June 2014 * DOI: https://doi.org/10.1038/nrn3750 SHARE THIS ARTICLE Anyone you share the following

link with will be able to read this content: Get shareable link Sorry, a shareable link is not currently available for this article. Copy to clipboard Provided by the Springer Nature

SharedIt content-sharing initiative