Inputs alter coupling strength

Access through your institution Buy or subscribe Mathy _et al_. and Turecek _et al_. performed patch-clamp recordings from coupled inferior olive neurons in rat brain slices. Mathy _et al_.

found that 1 Hz electrical stimulation of excitatory input reduced the coupling strength between neuron pairs (assessed by calculating the coupling coefficient) for over 15 minutes.

Importantly, the strength of excitatory chemical synapses in inferior olive neurons was not affected by stimulating glutamatergic input. > electrical stimulation of glutamatergic input 

strengthened coupling > between weakly coupled neurons This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through your institution Subscribe to

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support REFERENCES * Mathy, A., Clark, B. A. & Häusser, M. Synaptically induced long-term modulation of electrical coupling in the inferior olive. _Neuron_ 81, 1290–1296 (2014) Article

  CAS  PubMed  PubMed Central  Google Scholar  * Turecek, J. et al. NMDA receptor activation strengthens weak electrical coupling in mammalian brain. _Neuron_ 81, 1375–1388 (2014) Article 

CAS  PubMed  PubMed Central  Google Scholar  * Lefler, Y., Yarom, Y. & Uusisaari, M. Y. Cerebellar inhibitory input to the inferior olive decreases electrical coupling and blocks

subthreshold oscillations. _Neuron_ 81, 1389–1400 (2014) Article  CAS  PubMed  Google Scholar  Download references Authors * Leonie Welberg View author publications You can also search for

this author inPubMed Google Scholar RELATED LINKS RELATED LINKS RELATED LINKS IN NATURE RESEARCH Pereda, A. E. Electrical synapses and their functional interactions with chemical synapses.

_Nature Rev. Neurosci._ 15, 250–263 (2014) RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Welberg, L. Inputs alter coupling strength. _Nat Rev Neurosci_

15, 283 (2014). https://doi.org/10.1038/nrn3741 Download citation * Published: 17 April 2014 * Issue Date: May 2014 * DOI: https://doi.org/10.1038/nrn3741 SHARE THIS ARTICLE Anyone you

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