Microglial cell-mediated depression

Access through your institution Buy or subscribe Neuroinflammation and hypoxia are thought to interact synergistically to increase cognitive dysfunction in various brain disorders, including

stroke and neurodegenerative diseases, but the mechanisms underlying these interactions remain unclear. MacVicar and colleagues now show that, in the presence of hypoxia, activation of

microglial complement receptor 3 (CR3) by an inflammatory stimulus induces long-term depression (LTD) of synaptic transmission in the hippocampus, suggesting a means by which memory may be

impaired in these disorders. > The authors recorded field potentials in hippocampal slices from > wild-type rats and mice and CR3-knockout mice after exposure to LPS > and/or 

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taxes which are calculated during checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support REFERENCES * Zhang, J. et

al. Microglial CR3 activation triggers long-term synaptic depression in the hippocampus via NADPH oxidase. _Neuron_ http://dx.doi.org/10.1016/j.neuron.2014.01.043 (2014) Download references

Authors * Darran Yates View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS

ARTICLE Yates, D. Microglial cell-mediated depression. _Nat Rev Neurosci_ 15, 281 (2014). https://doi.org/10.1038/nrn3733 Download citation * Published: 09 April 2014 * Issue Date: May 2014

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