In Brief | Nature Reviews Neuroscience

Access through your institution Buy or subscribe TRAFFICKING OF PRION PROTEINS THROUGH A CAVEOLAE-MEDIATED ENDOSOMAL PATHWAY. Peters, P. J. _et al_. _J. Cell Biol._ 162, 703–717 (2003)

Peters _et al_. used immunoelectron microscopy to analyse the trafficking of the prion protein PrPC in CHO cells, and found that it uses an atypical endocytic pathway to reach the lysosomes.

This pathway does not involve clathrin-coated vesicles, but contains caveolin-1, a protein that is characteristic of caveolae. The data raise the possibility that transit through this

unusual pathway might be involved in the conversion of PrPC to the pathogenic form PrPSc. This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through

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https://doi.org/10.1038/nrn1229 Download citation * Issue Date: October 2003 * DOI: https://doi.org/10.1038/nrn1229 SHARE THIS ARTICLE Anyone you share the following link with will be able

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