Filling the canyon | Nature Reviews Microbiology
Filling the canyon | Nature Reviews Microbiology"
- Select a language for the TTS:
- UK English Female
- UK English Male
- US English Female
- US English Male
- Australian Female
- Australian Male
- Language selected: (auto detect) - EN
Play all audios:
Enterovirus D68 (EV-D68) is a poorly characterized member of the Enterovirus genus that is responsible for recent outbreaks of respiratory illness worldwide, yet no antiviral treatment is
available. Liu et al. solved the crystal structure of EV-D68 and showed that the capsid canyon — a deep surface depression that is the site of host receptor binding — is shallower and
narrower than that of other enteroviruses. Similarly to other enteroviruses, the EV-D68 canyon is occupied by a pocket factor, a fatty acid that stabilizes the virus by preventing viral
uncoating during transmission. The authors showed that pleconaril — an antiviral compound originally designed to inhibit rhinoviruses by binding to and stabilizing the capsid canyon —
replaces the pocket factor of EV-D68 and fills the capsid canyon, probably blocking receptor binding and preventing viral uncoating. These data establish pleconaril as a possible drug
candidate to treat EV-D68 infections.
Anyone you share the following link with will be able to read this content:
Trending News
MSP for kharif crops to be 1.5 times input cost: JaitleyBecome a MemberDark ModeBecome a MemberOperation SindoorRaghav's TakeState of EducationUncovering HateQisse KahaniyaanCl...
A test for the foreign-born | The WeekAMSTERDAM Immigration Minister Rita Verdonk has introduced a bill that would require some Dutch citizens to pass a test ...
Rotten meat for kids | The WeekA USA Today investigation has found that the government provides schools with beef and chicken that wouldn't meet the sa...
Elphinstone Stampede: Varun Grover Expresses Outrage Over TragedyBecome a MemberDark ModeBecome a MemberOperation SindoorRaghav's TakeState of EducationUncovering HateQisse KahaniyaanCl...
This cool interactive map lets you explore the world's languagesYou know about French, Spanish, and Russian, but what about Tohono Oodham, Karaim, and Iu Mien? There are thousands of l...
Latests News
Filling the canyon | Nature Reviews MicrobiologyEnterovirus D68 (EV-D68) is a poorly characterized member of the Enterovirus genus that is responsible for recent outbre...
Hillary clinton, bernie sanders, martin o'malley face off in south carolina debateThe three Democrats running for president, Hillary Clinton, Sen. Bernie Sanders (I-Vt.), and former Gov. Martin O'M...
Florida high school requires students be escorted to the bathroomPhysical attacks, drug deals, and bathroom sex are what Zephyrhills High School administrators are trying to put an end ...
Union density across the world, in one eye-popping chartResponding to Evan Soltas on union density, Matt Bruenig gives us the following amazing chart (which comes in turn from ...
Watch: home buyers protest #jaypeescam, threaten hunger strikeOver 500 home buyers stormed the gates of the Jaypee Infratech office in sector 128, Noida on 12 August. The buyers sat ...