Capturing bacterial chromosome conformation

Access through your institution Buy or subscribe Although chromosome organization in microorganisms has been investigated in single species, similar analyses of whole genomes in complex

environmental microbial communities have been limited. Marbouty _et al_. developed a metagenomic chromosome conformation capture approach (termed meta3C) for the characterization of the

average organization of individual genomes in mixed microbial communities. This approach, which is based on measuring the frequency with which two chromosomal segments come in contact, was

tested on an artificial mixture of bacterial species and an environmental sample of unknown composition; the authors identified genomic regions that could be matched to a specific species

and revealed the three-dimensional structure of the genomes in the mixed populations. Thus, meta3C has the potential to be used for the analysis of chromosome organization in environmental

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taxes which are calculated during checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support REFERENCES * Marbouty, M.

et al. Metagenomic chromosome conformation capture (meta3C) unveils the diversity of chromosome organization in microorganisms. _eLife_ 3, e03318 (2014) Article  Google Scholar  Download

references Authors * Andrea Du Toit View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE

CITE THIS ARTICLE Du Toit, A. Capturing bacterial chromosome conformation. _Nat Rev Microbiol_ 13, 68 (2015). https://doi.org/10.1038/nrmicro3426 Download citation * Published: 16 January

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