Cascade keeps its targets in the loop

This study presents cryo-electron microscopy structures of the type I-E Cascade and provides insights into PAM-dependent R-loop formation, Cas3 recruitment and substrate handover. Access

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Structure basis for directional R-loop formation and substrate handover mechanisms in type I CRISPR–Cas system. _Cell_ https://doi.org/10.1016/j.cell.2017.06.012. 2017 Article  Google

Scholar  Download references Authors * Andrea Du Toit View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions

ABOUT THIS ARTICLE CITE THIS ARTICLE Du Toit, A. Cascade keeps its targets in the loop. _Nat Rev Microbiol_ 15, 450 (2017). https://doi.org/10.1038/nrmicro.2017.80 Download citation *

Published: 10 July 2017 * Issue Date: August 2017 * DOI: https://doi.org/10.1038/nrmicro.2017.80 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this

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