Legionella's toolbox of effectors

Access through your institution Buy or subscribe _Legionella_ spp. effectors are delivered through the Icm/Dot type IV secretion system to the host cell, in which they subvert numerous host

pathways. The Icm/Dot system is required for intracellular growth and is present in all _Legionella_ species studied so far; however, with the exception of _L. pneumophila_, the secreted

effectors are mostly unknown. Burstein _et al_. sequenced and assembled the genomes of isolates from 38 different species and analysed them along three published genomes from _L.

pneumophila_, _Legionella longbeachae_ and _Legionella drancourtii_. To identify new effectors, the authors trained a machine-learning algorithm on proteins that were highly similar to known

_Legionella_ spp. effectors, taking into account features such as the Icm/Dot secretion signal or eukaryotic motifs. Using this algorithm, they identified 5,885 putative effectors; 2,170 of

which were novel without orthologues among known effectors. > _Legionella_ can turn exogenously acquired genes into effectors > relatively quickly This is a preview of subscription

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Learn more Buy this article * Purchase on SpringerLink * Instant access to full article PDF Buy now Prices may be subject to local taxes which are calculated during checkout ADDITIONAL

ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support REFERENCES * Burstein, D. et al. Genomic analysis of 38 _Legionella_ species

identifies large and diverse effector repertoires. _Nat. Genet._ http://dx.doi.org/10.1038/ng.3481 (2016) Download references Authors * Ursula Hofer View author publications You can also

search for this author inPubMed Google Scholar RELATED LINKS RELATED LINKS RELATED LINKS IN NATURE RESEARCH Escoll, P. _et al_. Targeting of host organelles by pathogenic bacteria: a

sophisticated subversion strategy. _Nat. Rev. Microbiol._ 14, 5–19 (2015) RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Hofer, U. _Legionella_'s

toolbox of effectors. _Nat Rev Microbiol_ 14, 133 (2016). https://doi.org/10.1038/nrmicro.2016.8 Download citation * Published: 25 January 2016 * Issue Date: March 2016 * DOI:

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