Recycling integrins | Nature Reviews Molecular Cell Biology

Access through your institution Buy or subscribe Based on the analogy between the changes in cell morphology during migration and mitosis, Pellinen and colleagues postulated that RAB21 —

which has been shown to regulate integrin trafficking during cell migration — could function to support this process during cell division. The authors show that targeted trafficking of

integrins to and from the cleavage furrow is regulated by RAB21 and is required for successful cytokinesis. Loss of RAB21 activity, defective integrin–RAB21 association or blocking of

integrin endocytosis all result in defective cytokinesis and binuclear cells. > ...highlight a role for integrin trafficking in cell division... This is a preview of subscription content,

access via your institution ACCESS OPTIONS Access through your institution Subscribe to this journal Receive 12 print issues and online access $209.00 per year only $17.42 per issue Learn

more Buy this article * Purchase on SpringerLink * Instant access to full article PDF Buy now Prices may be subject to local taxes which are calculated during checkout ADDITIONAL ACCESS

OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support ORIGINAL RESEARCH PAPERS * Caswell, P. T. et al. Rab-coupling protein coordinates

recycling of α5β1 integrin and EGFR1 to promote cell migration in 3D microenvironments. _J. Cell Biol._ 183, 143–155 6 Oct 2008 (doi: 10.1083/jcb200804140) Article  CAS  PubMed  PubMed

Central  Google Scholar  * Pellinen, T. et al. Integrin trafficking regulated by Rab21 is necessary for cytokinesis. _Dev. Cell_ 15, 371–385 (2008). Article  CAS  Google Scholar  Download

references Authors * Ekat Kritikou View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE

CITE THIS ARTICLE Kritikou, E. Recycling integrins. _Nat Rev Mol Cell Biol_ 9, 827 (2008). https://doi.org/10.1038/nrm2537 Download citation * Published: 15 October 2008 * Issue Date:

November 2008 * DOI: https://doi.org/10.1038/nrm2537 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a shareable link

is not currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative