Right place, right time | Nature Reviews Molecular Cell Biology

Access through your institution Buy or subscribe In a recent report in _Nature_, Julie Canman and colleagues challenge the widely held view that the symmetrical bipolar spindle is required

for cleavage-site formation. In an elegant set of experiments, they used a small-molecule inhibitor to block the kinesin Eg5, which is essential for establishing a bipolar spindle. As this

inhibition activated the spindle checkpoint, they blocked this checkpoint as well. What they found was that monopolar half-spindles formed, but that furrow formation and cytokinesis still

occurred. The cell-division plane formed on the side of the cell facing the chromosomes and not at the poles. So, these results showed that two opposing microtubule arrays are not essential

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Canman, J. C. et al. Determining the position of the cell division plane. _Nature_ 2003 August 6 (DOI: 10.1038/nature01860) * Alsop, G. B. & Zhang, D. Microtubules are the only

structural constituent of the spindle apparatus required for induction of cell cleavage. _J. Cell Biol._ 162, 383–390 (2003) Article  CAS  Google Scholar  Download references AUTHOR

INFORMATION AUTHORS AND AFFILIATIONS * Associate Editor, Nature, Mirella Bucci Authors * Mirella Bucci View author publications You can also search for this author inPubMed Google Scholar

RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Bucci, M. Right place, right time. _Nat Rev Mol Cell Biol_ 4, 675 (2003). https://doi.org/10.1038/nrm1213

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