Linking immune and emotional health

Access through your institution Buy or subscribe Indirect evidence suggesting a link between immune function and mood disorders is supported by the anxiety-like behaviour that is

characteristic of recombination-activating gene 1 (_Rag1_)−/− mice. This study showed that the presence of CD4+ T cells but not of CD8+ T cells in _Rag1__−/−_ OT-II-transgenic mice but not

in _Rag1__−/−_ OT-I-transgenic mice reverts the increased digging and marble-burying behaviours of _Rag1__−/−_ mice. Transient depletion or reconstitution of CD4+ or CD8+ T cells did not

affect these activites, which indicates that life-long immunodeficient conditions are required to affect behaviour. There were no differences in systemic factors or in brain anatomy that

could be an explanation for the altered emotional behaviour. Whole-brain microarray analysis showed that _Rag1__−/−_ OT-II mice have a genetic fingerprint more similar to wild-type mice than

to _Rag1__−/−_ mice. Nine main signalling pathways (including genes involved in various neuropsychological conditions) were significantly altered in _Rag1__−/−_ mice compared with wild-type

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are calculated during checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support REFERENCES * Rattazzi, L. et al. CD4+

but not CD8+ T cells revert the impaired emotional behavior of immunocompromised _RAG-1_-deficient mice. _Trans. Psych._ 3, e280 (2013) Article  CAS  Google Scholar  Download references

Authors * Kirsty Minton View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS

ARTICLE Minton, K. Linking immune and emotional health. _Nat Rev Immunol_ 13, 617 (2013). https://doi.org/10.1038/nri3529 Download citation * Published: 23 August 2013 * Issue Date:

September 2013 * DOI: https://doi.org/10.1038/nri3529 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a shareable

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