The ID of memory CD8+ T cells | Nature Reviews Immunology

Access through your institution Buy or subscribe Two recent studies published in _Nature Immunology_ describe the differential expression of the transcriptional regulator ID3 in short-lived

effector and long-lived memory CD8+ T cell subsets and its role in memory CD8+ T cell generation. Yang _et al_. identified two distinct CD8+ T cell populations (ID3low and ID3hi) in infected

mice. ID3 expression preceded the expression of long-lived memory markers, and ID3hiCD8+ T cells shared the phenotype and cytokine profile of long-lived memory T cells. Moreover, ID3hiCD8+

T cells generated long-lived memory cells following their transfer into infected hosts. Ji _et al_. observed that the transcriptional repressor BLIMP1 (also known as PRDM1) — which is

expressed in short-lived effector CD8+ T cells — downregulates ID3 expression. Both groups showed that ID3 is required for the generation of long-lived memory T cells because it promotes T

cell survival, and this may be linked to ID3-dependent expression of genes involved in DNA repair (Ji _et al_.). Although both groups reported that ID3 does not influence the expression of

ID2, Yang _et al_. found that loss of ID2 expression results in ID3 upregulation. Interleukin-2 (IL-2), IL-12 and IL-21 were shown to upregulate ID2 and downregulate ID3 expression,

suggesting that the balance between ID2 and ID3 regulates memory CD8+ T cell generation in response to cytokines. This is a preview of subscription content, access via your institution

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about institutional subscriptions * Read our FAQs * Contact customer support ORIGINAL RESEARCH PAPERS * Ji, Y. et al. Repression of the DNA-binding inhibitor Id3 by Blimp-1 limits the

formation of memory CD8+ T cells. _Nature Immunol._ 6 Nov 2011 (doi:10.1038/ni.2153) * Yang, C. Y. et al. The transcriptional regulators Id2 and Id3 control the formation of distinct memory

CD8+ T cell subsets. _Nature Immunol._ 6 Nov 2011 (doi:10.1038/ni.2158) Download references Authors * Maria Papatriantafyllou View author publications You can also search for this author

inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Papatriantafyllou, M. The ID of memory CD8+ T cells. _Nat Rev Immunol_ 11, 803

(2011). https://doi.org/10.1038/nri3127 Download citation * Published: 25 November 2011 * Issue Date: December 2011 * DOI: https://doi.org/10.1038/nri3127 SHARE THIS ARTICLE Anyone you share

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