Classifying pancreatic cancer using gene expression profiling

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Classifying pancreatic cancer using gene expression profiling"


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Despite some advances in our understanding of the molecular characteristics of pancreatic cancer, much more progress is needed. In a new study, RNA profiling of pancreatic cancers was used


to identify gene signatures of tumour cells and stromal cells to help predict patient outcomes. Access through your institution Buy or subscribe This is a preview of subscription content,


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more Buy this article * Purchase on SpringerLink * Instant access to full article PDF Buy now Prices may be subject to local taxes which are calculated during checkout ADDITIONAL ACCESS


OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support REFERENCES * Rahib, L. _ et al_. Projecting cancer incidence and deaths to 2030: the


unexpected burden of thyroid, liver, and pancreas cancers in the United States. _Cancer Res._ 74, 2913–2921 (2014). Article  CAS  Google Scholar  * Kaufman, B. _ et al_. Olaparib monotherapy


in patients with advanced cancer and a germline BRCA1/2 mutation. _J. Clin. Oncol._ 33, 244–250 (2015). Article  CAS  Google Scholar  * Le, D. T. _ et al_. PD-1 blockade in tumors with


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& Hingorani, S. R. Stromal reengineering to treat pancreas cancer. _Carcinogenesis_ 35, 1451–1460 (2014). Article  CAS  Google Scholar  * Iacobuzio-Donahue, C. A. _ et al_. DPC4 gene


status of the primary carcinoma correlates with patterns of failure in patients with pancreatic cancer. _J. Clin. Oncol._ 27, 1806–1813 (2009). Article  CAS  Google Scholar  * Ayars, M.


& Goggins, M. in _Molecular Alterations of Pancreatic Cancer_ (eds Simeone, D. & Maitra, A.) 185–208 (Springer, 2013). Book  Google Scholar  * Ruiz, C. _ et al_. Advancing a


clinically relevant perspective of the clonal nature of cancer. _Proc. Natl Acad. Sci. USA_ 108, 12054–12059 (2011). Article  CAS  Google Scholar  Download references ACKNOWLEDGEMENTS This


work was supported by S. Wojcicki and D. Troper, NIH grants (R01CA176828 and CA62924), the American Association for Cancer Research, the Lustgarten Foundation for Pancreatic Cancer Research,


the Jimmy V Foundation, and the Rolfe Pancreatic Cancer Foundation. AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Pathology, The Sol Goldman Pancreatic Cancer Research Centre,


The Johns Hopkins University School of Medicine, 1550 Orleans Street, Baltimore, 21231, MD, USA Michael Ayars & Michael Goggins Authors * Michael Ayars View author publications You can


also search for this author inPubMed Google Scholar * Michael Goggins View author publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence


to Michael Goggins. ETHICS DECLARATIONS COMPETING INTERESTS The authors declare no competing financial interests. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE


THIS ARTICLE Ayars, M., Goggins, M. Classifying pancreatic cancer using gene expression profiling. _Nat Rev Gastroenterol Hepatol_ 12, 613–614 (2015).


https://doi.org/10.1038/nrgastro.2015.180 Download citation * Published: 20 October 2015 * Issue Date: November 2015 * DOI: https://doi.org/10.1038/nrgastro.2015.180 SHARE THIS ARTICLE


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