Classifying pancreatic cancer using gene expression profiling
Classifying pancreatic cancer using gene expression profiling"
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Despite some advances in our understanding of the molecular characteristics of pancreatic cancer, much more progress is needed. In a new study, RNA profiling of pancreatic cancers was used
to identify gene signatures of tumour cells and stromal cells to help predict patient outcomes. Access through your institution Buy or subscribe This is a preview of subscription content,
access via your institution ACCESS OPTIONS Access through your institution Subscribe to this journal Receive 12 print issues and online access $209.00 per year only $17.42 per issue Learn
more Buy this article * Purchase on SpringerLink * Instant access to full article PDF Buy now Prices may be subject to local taxes which are calculated during checkout ADDITIONAL ACCESS
OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support REFERENCES * Rahib, L. _ et al_. Projecting cancer incidence and deaths to 2030: the
unexpected burden of thyroid, liver, and pancreas cancers in the United States. _Cancer Res._ 74, 2913–2921 (2014). Article CAS Google Scholar * Kaufman, B. _ et al_. Olaparib monotherapy
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stroma-specific subtypes of pancreatic ductal adenocarcinoma. _Nat. Genet._ http://dx.doi.org/10.1038/ng.3398. * Infante, J. R. _ et al_. Peritumoral fibroblast SPARC expression and patient
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& Hingorani, S. R. Stromal reengineering to treat pancreas cancer. _Carcinogenesis_ 35, 1451–1460 (2014). Article CAS Google Scholar * Iacobuzio-Donahue, C. A. _ et al_. DPC4 gene
status of the primary carcinoma correlates with patterns of failure in patients with pancreatic cancer. _J. Clin. Oncol._ 27, 1806–1813 (2009). Article CAS Google Scholar * Ayars, M.
& Goggins, M. in _Molecular Alterations of Pancreatic Cancer_ (eds Simeone, D. & Maitra, A.) 185–208 (Springer, 2013). Book Google Scholar * Ruiz, C. _ et al_. Advancing a
clinically relevant perspective of the clonal nature of cancer. _Proc. Natl Acad. Sci. USA_ 108, 12054–12059 (2011). Article CAS Google Scholar Download references ACKNOWLEDGEMENTS This
work was supported by S. Wojcicki and D. Troper, NIH grants (R01CA176828 and CA62924), the American Association for Cancer Research, the Lustgarten Foundation for Pancreatic Cancer Research,
the Jimmy V Foundation, and the Rolfe Pancreatic Cancer Foundation. AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Pathology, The Sol Goldman Pancreatic Cancer Research Centre,
The Johns Hopkins University School of Medicine, 1550 Orleans Street, Baltimore, 21231, MD, USA Michael Ayars & Michael Goggins Authors * Michael Ayars View author publications You can
also search for this author inPubMed Google Scholar * Michael Goggins View author publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence
to Michael Goggins. ETHICS DECLARATIONS COMPETING INTERESTS The authors declare no competing financial interests. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE
THIS ARTICLE Ayars, M., Goggins, M. Classifying pancreatic cancer using gene expression profiling. _Nat Rev Gastroenterol Hepatol_ 12, 613–614 (2015).
https://doi.org/10.1038/nrgastro.2015.180 Download citation * Published: 20 October 2015 * Issue Date: November 2015 * DOI: https://doi.org/10.1038/nrgastro.2015.180 SHARE THIS ARTICLE
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