Metabolic make-up of nash: from fat and sugar to amino acids

Nature

Metabolic make-up of nash: from fat and sugar to amino acids"


Play all audios:

Loading...

NAFLD is regarded unquestionably as one of the components of the metabolic syndrome. Hence, metabolic perturbations occurring in the fatty liver become a systemic metabolic derangement. The


phenotypic switching from fatty liver to NASH entails a reprogramming of liver metabolism to fit a stressful metabolic environment. Access through your institution Buy or subscribe This is a


preview of subscription content, access via your institution RELEVANT ARTICLES Open Access articles citing this article. * B-CELL LYMPHOMA 6 ALLEVIATES NONALCOHOLIC FATTY LIVER DISEASE IN


MICE THROUGH SUPPRESSION OF FATTY ACID TRANSPORTER CD36 * Hao Zhang * , Yue Li *  … Jiahong Xia _Cell Death & Disease_ Open Access 18 April 2022 * HEAT SHOCK PROTEIN 27 IS DOWN-REGULATED


IN BALLOONED HEPATOCYTES OF PATIENTS WITH NONALCOHOLIC STEATOHEPATITIS (NASH) * Silvia Sookoian * , Gustavo O. Castaño *  … Carlos J. Pirola _Scientific Reports_ Open Access 03 March 2016


ACCESS OPTIONS Access through your institution Subscribe to this journal Receive 12 print issues and online access $209.00 per year only $17.42 per issue Learn more Buy this article *


Purchase on SpringerLink * Instant access to full article PDF Buy now Prices may be subject to local taxes which are calculated during checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn


about institutional subscriptions * Read our FAQs * Contact customer support REFERENCES * Mardinoglu, A. _ et al_. Genome-scale metabolic modelling of hepatocytes reveals serine deficiency


in patients with non-alcoholic fatty liver disease. _Nat. Commun._ 5, 3083 (2014). Article  Google Scholar  * Speliotes, E.K. _ et al_. Genome-wide association analysis identifies variants


associated with nonalcoholic fatty liver disease that have distinct effects on metabolic traits. _PLoS Genet._ 7, e1001324 (2011). Article  CAS  Google Scholar  * Newgard, C.B. _ et al_. A


branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance. _Cell Metab._ 9, 311–326 (2009). Article  CAS  Google


Scholar  * Wang, T.J. _ et al_. Metabolite profiles and the risk of developing diabetes. _Nat. Med._ 17, 448–453 (2011). Article  Google Scholar  * Shah, S.H. _ et al_. Association of a


peripheral blood metabolic profile with coronary artery disease and risk of subsequent cardiovascular events. _Circ. Cardiovasc. Genet._ 3, 207–214 (2010). Article  CAS  Google Scholar  *


Sookoian, S. _ et al_. Epigenetic regulation of insulin resistance in nonalcoholic fatty liver disease: impact of liver methylation of the peroxisome proliferator-activated receptor gamma


coactivator 1α promoter. _Hepatology_ 52, 1992–2000 (2010). Article  CAS  Google Scholar  * Pirola, C.J. _ et al_. Epigenetic modification of liver mitochondrial DNA is associated with


histological severity of nonalcoholic fatty liver disease. _Gut_ 62, 1356–1363 (2013). Article  CAS  Google Scholar  * Sanyal, A.J. _ et al_. Nonalcoholic steatohepatitis: association of


insulin resistance and mitochondrial abnormalities. _Gastroenterology_ 120, 1183–1192 (2001). Article  CAS  Google Scholar  * Sookoian, S. & Pirola, C.J. Meta-analysis of the influence


of I148M variant of patatin-like phospholipase domain containing 3 gene (PNPLA3) on the susceptibility and histological severity of nonalcoholic fatty liver disease. _Hepatology_ 53,


1883–1894 (2011). Article  CAS  Google Scholar  * Anstee, Q.M. & Day, C. P. The genetics of NAFLD. _Nat. Rev. Gastroenterol. Hepatol._ 10, 645–655 (2013). Article  CAS  Google Scholar 


Download references ACKNOWLEDGEMENTS The authors are partially supported by grants PICT 2010-0441 and PICT 2012-159 (Agencia Nacional de Promoción Científica y Tecnológica), and UBACYT CM04


(Universidad de Buenos Aires). S.S. and C.J.P. belong to Consejo Nacional de Investigaciones Científicas (CONICET). AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Clinical and


Molecular Hepatology, Institute of Medical Research A Lanari-IDIM, University of Buenos Aires–National Scientific and Technical Research Council (CONICET), Combatiente de Malvinas 3150,


Ciudad Autónoma de Buenos Aires 1427, Argentina Silvia Sookoian * Department of Molecular Genetics and Biology of Complex Diseases, Institute of Medical Research A Lanari-IDIM, University of


Buenos Aires–National Scientific and Technical Research Council (CONICET), Combatiente de Malvinas 3150, Ciudad Autónoma de Buenos Aires 1427, Argentina Carlos J. Pirola Authors * Silvia


Sookoian View author publications You can also search for this author inPubMed Google Scholar * Carlos J. Pirola View author publications You can also search for this author inPubMed Google


Scholar CORRESPONDING AUTHOR Correspondence to Silvia Sookoian. ETHICS DECLARATIONS COMPETING INTERESTS The authors declare no competing financial interests. POWERPOINT SLIDES POWERPOINT


SLIDE FOR FIG. 1 RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Sookoian, S., Pirola, C. Metabolic make-up of NASH: from fat and sugar to amino acids.


_Nat Rev Gastroenterol Hepatol_ 11, 205–207 (2014). https://doi.org/10.1038/nrgastro.2014.25 Download citation * Published: 25 February 2014 * Issue Date: April 2014 * DOI:


https://doi.org/10.1038/nrgastro.2014.25 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a shareable link is not


currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative


Trending News

Gwyneth paltrow ’s cape steals the limelight at oscars

Hollywood’s bevy had eyes poppin’ at the Oscar red carpet. But who got it right, and who didn’t, city designers take the...

Lindsay Lohan strips off in church in latest movie 'Machete'

Jessica Alba isn't the only to shed clothes for new flick Machete, Lindsay Lohan too has stripped off for the film.DNA T...

Riverdale season 4: Fans ‘in tears’ at emotional Luke Perry tribute episode

WARNING: The following article contains spoilers from Riverdale season 4, episode one.Riverdale released the first episo...

Agniveer SSR Navy Recruitment 2022: One day left to apply for 2800 posts at joinindiannavy.gov.in

Indian Navy Recruitment 2022: Interested candidates can apply through the official website, joinindiannavy.gov.in.Indian...

Govt to unveil reworked policy on mining soon

LATESTWEBSTORYTRENDINGTrump vs Musk: Trump Rules Out Mending Ties With Elon Musk, Issues 'Very Serious' Warning | USA Ne...

Latests News

Metabolic make-up of nash: from fat and sugar to amino acids

NAFLD is regarded unquestionably as one of the components of the metabolic syndrome. Hence, metabolic perturbations occu...

Marcus Rashford told brutal Man Utd truth and how he can 'fix it' at Aston Villa

Marcus Rashford told brutal Man Utd truth and how he can 'fix it' at Aston VillaRashford has been told how to revive his...

How tall is Celia actress Karen Connell in The Bastard Son and the Devil Himself?

The Bastard Son and the Devil Himself is based on a popular young adult novel by Sally Green and the Netflix adaptation ...

Oscars 2022: disney’s ‘encanto’ shows healing from intergenerational trauma

Disney’s _Encanto_ depicts a multigenerational story about a grandmother and her family endowed with magic gifts, who we...

Mass tests are vital to contain coronavirus spread in India, experts say after first death

“India has far more infected cases out there than we know. Community transmission is already happening and we’ll know ab...

Top