Metabolic make-up of nash: from fat and sugar to amino acids
Metabolic make-up of nash: from fat and sugar to amino acids"
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NAFLD is regarded unquestionably as one of the components of the metabolic syndrome. Hence, metabolic perturbations occurring in the fatty liver become a systemic metabolic derangement. The
phenotypic switching from fatty liver to NASH entails a reprogramming of liver metabolism to fit a stressful metabolic environment. Access through your institution Buy or subscribe This is a
preview of subscription content, access via your institution RELEVANT ARTICLES Open Access articles citing this article. * B-CELL LYMPHOMA 6 ALLEVIATES NONALCOHOLIC FATTY LIVER DISEASE IN
MICE THROUGH SUPPRESSION OF FATTY ACID TRANSPORTER CD36 * Hao Zhang * , Yue Li * … Jiahong Xia _Cell Death & Disease_ Open Access 18 April 2022 * HEAT SHOCK PROTEIN 27 IS DOWN-REGULATED
IN BALLOONED HEPATOCYTES OF PATIENTS WITH NONALCOHOLIC STEATOHEPATITIS (NASH) * Silvia Sookoian * , Gustavo O. Castaño * … Carlos J. Pirola _Scientific Reports_ Open Access 03 March 2016
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Purchase on SpringerLink * Instant access to full article PDF Buy now Prices may be subject to local taxes which are calculated during checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn
about institutional subscriptions * Read our FAQs * Contact customer support REFERENCES * Mardinoglu, A. _ et al_. Genome-scale metabolic modelling of hepatocytes reveals serine deficiency
in patients with non-alcoholic fatty liver disease. _Nat. Commun._ 5, 3083 (2014). Article Google Scholar * Speliotes, E.K. _ et al_. Genome-wide association analysis identifies variants
associated with nonalcoholic fatty liver disease that have distinct effects on metabolic traits. _PLoS Genet._ 7, e1001324 (2011). Article CAS Google Scholar * Newgard, C.B. _ et al_. A
branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance. _Cell Metab._ 9, 311–326 (2009). Article CAS Google
Scholar * Wang, T.J. _ et al_. Metabolite profiles and the risk of developing diabetes. _Nat. Med._ 17, 448–453 (2011). Article Google Scholar * Shah, S.H. _ et al_. Association of a
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Sookoian, S. _ et al_. Epigenetic regulation of insulin resistance in nonalcoholic fatty liver disease: impact of liver methylation of the peroxisome proliferator-activated receptor gamma
coactivator 1α promoter. _Hepatology_ 52, 1992–2000 (2010). Article CAS Google Scholar * Pirola, C.J. _ et al_. Epigenetic modification of liver mitochondrial DNA is associated with
histological severity of nonalcoholic fatty liver disease. _Gut_ 62, 1356–1363 (2013). Article CAS Google Scholar * Sanyal, A.J. _ et al_. Nonalcoholic steatohepatitis: association of
insulin resistance and mitochondrial abnormalities. _Gastroenterology_ 120, 1183–1192 (2001). Article CAS Google Scholar * Sookoian, S. & Pirola, C.J. Meta-analysis of the influence
of I148M variant of patatin-like phospholipase domain containing 3 gene (PNPLA3) on the susceptibility and histological severity of nonalcoholic fatty liver disease. _Hepatology_ 53,
1883–1894 (2011). Article CAS Google Scholar * Anstee, Q.M. & Day, C. P. The genetics of NAFLD. _Nat. Rev. Gastroenterol. Hepatol._ 10, 645–655 (2013). Article CAS Google Scholar
Download references ACKNOWLEDGEMENTS The authors are partially supported by grants PICT 2010-0441 and PICT 2012-159 (Agencia Nacional de Promoción Científica y Tecnológica), and UBACYT CM04
(Universidad de Buenos Aires). S.S. and C.J.P. belong to Consejo Nacional de Investigaciones Científicas (CONICET). AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Clinical and
Molecular Hepatology, Institute of Medical Research A Lanari-IDIM, University of Buenos Aires–National Scientific and Technical Research Council (CONICET), Combatiente de Malvinas 3150,
Ciudad Autónoma de Buenos Aires 1427, Argentina Silvia Sookoian * Department of Molecular Genetics and Biology of Complex Diseases, Institute of Medical Research A Lanari-IDIM, University of
Buenos Aires–National Scientific and Technical Research Council (CONICET), Combatiente de Malvinas 3150, Ciudad Autónoma de Buenos Aires 1427, Argentina Carlos J. Pirola Authors * Silvia
Sookoian View author publications You can also search for this author inPubMed Google Scholar * Carlos J. Pirola View author publications You can also search for this author inPubMed Google
Scholar CORRESPONDING AUTHOR Correspondence to Silvia Sookoian. ETHICS DECLARATIONS COMPETING INTERESTS The authors declare no competing financial interests. POWERPOINT SLIDES POWERPOINT
SLIDE FOR FIG. 1 RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Sookoian, S., Pirola, C. Metabolic make-up of NASH: from fat and sugar to amino acids.
_Nat Rev Gastroenterol Hepatol_ 11, 205–207 (2014). https://doi.org/10.1038/nrgastro.2014.25 Download citation * Published: 25 February 2014 * Issue Date: April 2014 * DOI:
https://doi.org/10.1038/nrgastro.2014.25 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a shareable link is not
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