Metabolic make-up of nash: from fat and sugar to amino acids

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Metabolic make-up of nash: from fat and sugar to amino acids"


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NAFLD is regarded unquestionably as one of the components of the metabolic syndrome. Hence, metabolic perturbations occurring in the fatty liver become a systemic metabolic derangement. The


phenotypic switching from fatty liver to NASH entails a reprogramming of liver metabolism to fit a stressful metabolic environment. Access through your institution Buy or subscribe This is a


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during checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support REFERENCES * Mardinoglu, A. _ et al_. Genome-scale


metabolic modelling of hepatocytes reveals serine deficiency in patients with non-alcoholic fatty liver disease. _Nat. Commun._ 5, 3083 (2014). Article  Google Scholar  * Speliotes, E.K. _


et al_. Genome-wide association analysis identifies variants associated with nonalcoholic fatty liver disease that have distinct effects on metabolic traits. _PLoS Genet._ 7, e1001324


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  * Sookoian, S. & Pirola, C.J. Meta-analysis of the influence of I148M variant of patatin-like phospholipase domain containing 3 gene (PNPLA3) on the susceptibility and histological


severity of nonalcoholic fatty liver disease. _Hepatology_ 53, 1883–1894 (2011). Article  CAS  Google Scholar  * Anstee, Q.M. & Day, C. P. The genetics of NAFLD. _Nat. Rev.


Gastroenterol. Hepatol._ 10, 645–655 (2013). Article  CAS  Google Scholar  Download references ACKNOWLEDGEMENTS The authors are partially supported by grants PICT 2010-0441 and PICT 2012-159


(Agencia Nacional de Promoción Científica y Tecnológica), and UBACYT CM04 (Universidad de Buenos Aires). S.S. and C.J.P. belong to Consejo Nacional de Investigaciones Científicas (CONICET).


AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Clinical and Molecular Hepatology, Institute of Medical Research A Lanari-IDIM, University of Buenos Aires–National Scientific


and Technical Research Council (CONICET), Combatiente de Malvinas 3150, Ciudad Autónoma de Buenos Aires 1427, Argentina Silvia Sookoian * Department of Molecular Genetics and Biology of


Complex Diseases, Institute of Medical Research A Lanari-IDIM, University of Buenos Aires–National Scientific and Technical Research Council (CONICET), Combatiente de Malvinas 3150, Ciudad


Autónoma de Buenos Aires 1427, Argentina Carlos J. Pirola Authors * Silvia Sookoian View author publications You can also search for this author inPubMed Google Scholar * Carlos J. Pirola


View author publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to Silvia Sookoian. ETHICS DECLARATIONS COMPETING INTERESTS The


authors declare no competing financial interests. POWERPOINT SLIDES POWERPOINT SLIDE FOR FIG. 1 RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Sookoian,


S., Pirola, C. Metabolic make-up of NASH: from fat and sugar to amino acids. _Nat Rev Gastroenterol Hepatol_ 11, 205–207 (2014). https://doi.org/10.1038/nrgastro.2014.25 Download citation *


Published: 25 February 2014 * Issue Date: April 2014 * DOI: https://doi.org/10.1038/nrgastro.2014.25 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this


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