Transcriptome-wide n6-methyladenosine analysis

Access through your institution Buy or subscribe Two groups have developed a technique for analysing the transcriptome-wide distribution of the RNA modification _N_6-methyladenosine (m6A)

that incorporates antibody-mediated enrichment of the modification coupled with sequencing. Notably, in humans and mice, there was an enrichment for the mark around stop codons. In addition,

conservation of modification sites between these species indicates some functionality for this mark, as does its tissue-specific distribution in human RNAs. This is a preview of

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ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support CHANGE HISTORY * _ 03 JULY 2012 The title of one of the papers

referenced in this article contained an important typographical error. The correct title is 'Comprehensive analysis of mRNA methylation reveals enrichment in 3′ UTRs and near stop

codons'. _ ORIGINAL RESEARCH PAPERS * Meyer, K. D. et al. Comprehensive analysis of mRNA methylation reveals enrichment in 3′ UTRs and near stop codons. _Cell_ 17 May 2012

(doi:10.1016/j.cell.2012.05.003) Article  CAS  Google Scholar  * Dominissini, D. et al. Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq. _Nature_ 485, 201–205 (2012)

Article  CAS  Google Scholar  Download references Authors * Hannah Stower View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints

and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Stower, H. Transcriptome-wide _N_6-methyladenosine analysis. _Nat Rev Genet_ 13, 452 (2012). https://doi.org/10.1038/nrg3280 Download

citation * Published: 18 June 2012 * Issue Date: July 2012 * DOI: https://doi.org/10.1038/nrg3280 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this

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