Unscrambling the egg–sperm divide
Unscrambling the egg–sperm divide"
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Key to the production of gametes is the time at which the germ cells they are derived from enter meiosis. In mice, meiosis is initiated in females during embryonic development (at E13.5),
whereas in males this occurs only after birth. This timing is crucial, as the later meiosis of male germ cells allows sperm rather than eggs to be made.
David Page and colleagues showed that an RA receptor (RAR) antagonist suppresses the expression of a pre-meiotic marker (Stra8) in cultured mouse embryonic ovaries. Furthermore, although
Stra8 is not normally expressed in the male gonad until after birth, addition of RA to testes in culture stimulates expression of the marker. This led the authors to propose that RA is
required for germ cells to enter meiosis, and indicates that regulated RA degradation might control the timing of this event.
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