Soft-hearted fish | Nature Reviews Genetics

Access through your institution Buy or subscribe The authors identified the mutant by screening a mutagenized zebrafish library for mutations in the mutation cluster region (MCR) of the

tumour supressor gene _adenomatous polyposis coli_ ( _apc_ ). A second independent mutation was fortuitously identified in a forward genetic screen that was carried out by one of their

collaborators. Mutations in the MCR have previously been shown to constitutively activate the Wnt/β-catenin signalling pathway and lead to the development of colorectal tumours in mice.

Similar to the mouse mutants, the zebrafish _apc_ mutants activated this pathway. However, unlike their furry counterparts, the homozygous mutant fish were able to complete gastrulation,

probably because wild-type maternal Apc was able to rescue the fish mutants. This was an important breakthrough because it allowed the effects of _apc_ mutations on later developmental

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RESEARCH PAPER * Hurlstone, A. et al. The Wnt/β-catenin signalling pathway regulates valve formation. _Nature_ 425, 633–637 (2003) Article  CAS  Google Scholar  FURTHER READING * Harvey, R.

Patterning the vertebrate heart. _Nature Rev. Genet._ 3, 554–556 (2002) Article  Google Scholar  * Stainier, D. Y. Zebrafish genetics and vertebrate heart formation. _Nature Rev. Genet._ 2,

39–48 (2001) Article  CAS  Google Scholar  Download references Authors * Nick Campbell View author publications You can also search for this author inPubMed Google Scholar RELATED LINKS

RELATED LINKS WEB SITE Hans Clevers' laboratory RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Campbell, N. Soft-hearted fish. _Nat Rev Genet_ 4,

934–935 (2003). https://doi.org/10.1038/nrg1241 Download citation * Issue Date: 01 December 2003 * DOI: https://doi.org/10.1038/nrg1241 SHARE THIS ARTICLE Anyone you share the following link

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