Circadian clock and cell division: unveiling the link
Circadian clock and cell division: unveiling the link"
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Using a mouse model with a partial hepatectomy (PH), Okamura and colleagues analysed the relationship between the circadian clock and the cell cycle. Liver cells from wild-type mice that
have undergone a PH rapidly re-enter the cell cycle and restore the liver in a few days. The rate of liver regrowth was studied in mice that were maintained in a 12-hour light/dark cycle,
with a PH on the liver performed at the start of the 12-hour light period (ZT0) and 8 hours later (ZT8). The results of BrdU incorporation, which marks cell proliferation, indicated that
although S-phase kinetics were similar for both ZT0 and ZT8, there was a delay in cells entering mitosis if the PH was performed at ZT0. This shows that the timing of the hepatectomy affects
cell-cycle progression in the regenerating cells. Peaks of the cell-cycle kinase Cdc2 and mRNA levels of other cell-cycle regulators, including Wee1 — which is a known Cdc2 regulator —
mimicked the BrdU incorporation peaks and pointed to the involvement of cell-cycle regulators in this process.
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