Antiplatelet agent promotes bone formation

Access through your institution Buy or subscribe Targeting adenosine receptors might be a promising approach to promote bone regeneration, according to new research. The platelet aggregation

inhibitor ticagrelor, which also blocks cellular uptake of adenosine, inhibited osteoclast differentiation _in vitro_, an effect that was abrogated by inhibition of the A2A adenosine

receptor. Moreover, ticagrelor and clopidogrel (another antiplatelet agent) promoted bone regeneration in mice with calvarial defects as effectively as BMP2, a growth factor currently

marketed to promote bone growth and regeneration. This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through your institution Subscribe to this

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support REFERENCES * Mediero, A. _ et al_. Ticagrelor regulates osteoblast and osteoclast function and promotes bone formation _in vivo_ via an adenosine-dependent mechanism. _FASEB J._

http://dx.doi.org/10.1096/fj.201600616R (2016) Download references Authors * David Holmes View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND

PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Holmes, D. Antiplatelet agent promotes bone formation. _Nat Rev Endocrinol_ 12, 626 (2016).

https://doi.org/10.1038/nrendo.2016.145 Download citation * Published: 26 August 2016 * Issue Date: November 2016 * DOI: https://doi.org/10.1038/nrendo.2016.145 SHARE THIS ARTICLE Anyone you

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