Making steps in stroke therapy

Access through your institution Buy or subscribe Rupture or blockage of a blood vessel in the brain causes rapid cell death in the core of the injured region, and triggers mechanisms in the

surrounding area — the penumbra — that lead, for example, to increases in the concentrations of intracellular Ca2+ and reactive oxygen species (ROS), which initiate cell death. Targeting

these mechanisms provides a promising route for the development of therapies for the treatment of stroke. One such strategy, reported by Jiang and colleagues, involved using the metal

chelator PAN-811 (also known as Triapine) to 'mop up' intracellular Ca2+ ions. PAN-811 was also shown to scavenge ROS, and so protects neurons from the degenerative effects of both

chemical species. In a rat model of ischaemic stroke, intracerebroventricular administration of PAN-811 1 hour after occlusion of the middle cerebral artery (MCA) led to a 59% reduction in

infarct volume. In addition, PAN-811 has been shown to have a favourable safety and pharmacodynamic profile in the range required for neuroprotection. This is a preview of subscription

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ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support ORIGINAL RESEARCH PAPERS * Jiang, Z.-G. et al. A multifunctional cytoprotective

agent that reduces neurodegeneration after ischemia. _Proc. Natl Acad. Sci. USA_ 103, 1581–1586 (2006) Article  CAS  Google Scholar  * Kawano, T. et al. Prostaglandin E2 EP1 receptors:

downstream effectors of COX-2 neurotoxicity. _Nature Med._ 12, 225–229 (2006) Article  CAS  Google Scholar  * Nishimura, N. et al. Targeted insult to subsurface cortical blood vessels using

ultrashort laser pulses: three models of stroke. _Nature Methods_ 3, 99–108 (2006) Article  CAS  Google Scholar  Download references Authors * Samantha Barton View author publications You

can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Barton, S. Making steps in stroke therapy. _Nat

Rev Drug Discov_ 5, 187 (2006). https://doi.org/10.1038/nrd2002 Download citation * Issue Date: 01 March 2006 * DOI: https://doi.org/10.1038/nrd2002 SHARE THIS ARTICLE Anyone you share the

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