Wnt signalling required for pancreatic carcinogenesis

Although signalling through the Wnt/β-catenin pathway is associated with pancreatic ductal adenocarcinoma, only now has this pathway been shown to be critical for tumorigenesis. This was

shown through experiments on β-catenin-null acinar cells, which could not undergo metaplastic transformation to ductal cells—a process central to the development of premalignant lesions.

Furthermore, targeting the Wnt pathway with a specific antibody (OMP-18R5) in a transgenic mouse model of pancreatic cancer revealed normal acinar structures and fewer lesions than untreated

mice. ORIGINAL RESEARCH PAPER * Zhang, Y. _ et al_. Canonical Wnt signaling is required for pancreatic carcinogenesis. _Cancer Res._ doi:10.1158/0008-5472.CAN-12-4384 Download references

RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Wnt signalling required for pancreatic carcinogenesis. _Nat Rev Clin Oncol_ 10, 428 (2013).

https://doi.org/10.1038/nrclinonc.2013.116 Download citation * Published: 02 July 2013 * Issue Date: August 2013 * DOI: https://doi.org/10.1038/nrclinonc.2013.116 SHARE THIS ARTICLE Anyone

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