Release the B cell | Nature Reviews Cancer

Access through your institution Buy or subscribe Germinal centre B cells (GCBs) are strictly localized to lymphoid organs, unlike those of GCB-like diffuse large B cell lymphoma (GCB-DLBCL).

Muppidi _et al_. found that GCB-DLBCL-associated inactivating mutations in _GNA13_, which encodes the guanine nucleotide binding protein Gα13, allow AKT activation and cell migration. Loss

of Gα13 in mice caused dissemination of GCBs, and these mice developed GCB-derived lymphoma. GCB-DLBCL-associated mutations were also found in ARHGEF1, a Gα13 effector, the loss of which

also caused GCB dissemination in mice, indicating that altered Gα13 signalling promotes GCB dissemination. This is a preview of subscription content, access via your institution ACCESS

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institutional subscriptions * Read our FAQs * Contact customer support REFERENCES * Muppidi, J. R. et al. Loss of signalling via Gα13 in germinal centre B-cell-derived lymphoma. _Nature_

http://dx.doi.org/10.1038/nature13765 (2014) Download references Authors * Gemma K. Alderton View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND

PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Alderton, G. Release the B cell. _Nat Rev Cancer_ 14, 707 (2014). https://doi.org/10.1038/nrc3856 Download citation

* Published: 24 October 2014 * Issue Date: November 2014 * DOI: https://doi.org/10.1038/nrc3856 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content:

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