Release the B cell | Nature Reviews Cancer

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Release the B cell | Nature Reviews Cancer"


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Access through your institution Buy or subscribe Germinal centre B cells (GCBs) are strictly localized to lymphoid organs, unlike those of GCB-like diffuse large B cell lymphoma (GCB-DLBCL).


Muppidi _et al_. found that GCB-DLBCL-associated inactivating mutations in _GNA13_, which encodes the guanine nucleotide binding protein Gα13, allow AKT activation and cell migration. Loss


of Gα13 in mice caused dissemination of GCBs, and these mice developed GCB-derived lymphoma. GCB-DLBCL-associated mutations were also found in ARHGEF1, a Gα13 effector, the loss of which


also caused GCB dissemination in mice, indicating that altered Gα13 signalling promotes GCB dissemination. This is a preview of subscription content, access via your institution ACCESS


OPTIONS Access through your institution Subscribe to this journal Receive 12 print issues and online access $209.00 per year only $17.42 per issue Learn more Buy this article * Purchase on


SpringerLink * Instant access to full article PDF Buy now Prices may be subject to local taxes which are calculated during checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn about


institutional subscriptions * Read our FAQs * Contact customer support REFERENCES * Muppidi, J. R. et al. Loss of signalling via Gα13 in germinal centre B-cell-derived lymphoma. _Nature_


http://dx.doi.org/10.1038/nature13765 (2014) Download references Authors * Gemma K. Alderton View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND


PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Alderton, G. Release the B cell. _Nat Rev Cancer_ 14, 707 (2014). https://doi.org/10.1038/nrc3856 Download citation


* Published: 24 October 2014 * Issue Date: November 2014 * DOI: https://doi.org/10.1038/nrc3856 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content:


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