Route master | Nature Reviews Cancer

Access through your institution Buy or subscribe The integrity of vascular walls depends on the interaction between the outer sheath of mural cells and the inner endothelial cells.

PDGFB-mediated signal transduction regulates mural-cell function, and is modulated by the interactions of PDGFB with PDGFRβ and various accessory factors. This prompted Weiss and colleagues

to investigate a previous report that the expression of MT1-MMP specifically in mural cells is associated with the recruitment of these cells to developing vasculature. Histological analysis

showed that the aortae of young _MT1-MMP__−/−_ mice were defective; but in culture, _MT1-MMP__−/−_ and _MT1-MMP_+/+ mural cells were visually indistinguishable. However, treating the

_MT1-MMP__−/−_ cells with various growth factors revealed defects in their growth and chemotactic responses, but only when PDGFB was used to stimulate the cells. This is a preview of

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ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support ORIGINAL RESEARCH PAPER * Lehti, K. et al. An MT1-MMP–PDGF

receptor-β axis regulates mural cell investment of the microvasculature. _Genes Dev._ 1 Apr 2005 (10.1101/gad.1294605) Download references Authors * Lesley Cunliffe View author publications

You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Cunliffe, L. Route master. _Nat Rev Cancer_

5, 338 (2005). https://doi.org/10.1038/nrc1623 Download citation * Issue Date: 01 May 2005 * DOI: https://doi.org/10.1038/nrc1623 SHARE THIS ARTICLE Anyone you share the following link with

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