Space shuttle | Nature Reviews Cancer

Access through your institution Buy or subscribe In normal cells, NPM shuttles between the nucleus and cytoplasm, and is most frequently found in the nucleolus. It is thought to have a

tumour-suppressor function, and is a molecular chaperone that might regulate the ARF–p53 pathway. However, it also acts oncogenically in some leukaemias and lymphomas, as the _NPM_ gene is a

partner in cancer-associated translocations. In this study, the authors investigated the subcellular location of NPM in 591 specimens from patients with AML, with a view to discovering

whether this might affect its tumour-suppressor function. They found that in 208 of the samples (35%), NPM was located in the cytoplasm (NPMc+). This pattern was observed across all of the

different leukaemia FAB (French–American–British) subtypes tested, usually associated with CD34 negativity, but was only seen in cells from patients with primary AML. In secondary AML cells,

NPM localization was exclusively nuclear. Significantly, 85% of patients with NPMc+ had normal karyotypes, compared with 27% of patients with NPMc−. So, cytoplasmic NPM characterizes a

distinct subgroup of patients with AML who have a normal karyotype — a group that was previously difficult to stratify. This is a preview of subscription content, access via your institution

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about institutional subscriptions * Read our FAQs * Contact customer support ORIGINAL RESEARCH PAPER * Falini, B. et al. Cytosplamic nucleophosmin in acute myelogenous leukemia with a normal

karyotype. _N. Engl. J. Med._ 352, 254–266 (2005) Article  CAS  Google Scholar  Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * NPG Executive Editor, Leukemia, Emma

Greenwood Authors * Emma Greenwood View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE

CITE THIS ARTICLE Greenwood, E. Space shuttle. _Nat Rev Cancer_ 5, 157 (2005). https://doi.org/10.1038/nrc1572 Download citation * Published: 18 February 2005 * Issue Date: 01 March 2005 *

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