Sleeping with the hypothalamus: emerging therapeutic targets for sleep disorders

ABSTRACT Delineating the basic mechanisms that regulate sleep will likely result in the development of better treatments for sleep disorders. The hypothalamus is now recognized as a key

center for sleep regulation, with hypothalamic neurotransmitter systems providing the framework for therapeutic advances. An increased awareness of the close interaction between sleep and

homeostatic systems is also emerging. Progress has occurred in the understanding of narcolepsy—molecular techniques have identified the lateral hypothalamic hypocretin (orexin) neuropeptide

system as key to the disorder. Other sleep disorders are now being tackled in the same way and are likely to yield to efforts combining basic and clinical research. Here we highlight the

role of the hypothalamus in sleep physiology and discuss neurotransmitter systems, such as adenosine, dopamine, GABA, histamine and hypocretin, that may have therapeutic applications for

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Contact customer support SIMILAR CONTENT BEING VIEWED BY OTHERS SLEEP AND CIRCADIAN RHYTHMICITY AS ENTANGLED PROCESSES SERVING HOMEOSTASIS Article 01 December 2023 NEURO-ORCHESTRATION OF

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Stanford University Center for Narcolepsy, 701 Welch Road B, Room 145, Palo Alto, 94304-5742, California, USA Emmanuel Mignot, Shahrad Taheri & Seiji Nishino Authors * Emmanuel Mignot

View author publications You can also search for this author inPubMed Google Scholar * Shahrad Taheri View author publications You can also search for this author inPubMed Google Scholar *

Seiji Nishino View author publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to Emmanuel Mignot. RIGHTS AND PERMISSIONS Reprints and

permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Mignot, E., Taheri, S. & Nishino, S. Sleeping with the hypothalamus: emerging therapeutic targets for sleep disorders. _Nat Neurosci_ 5

(Suppl 11), 1071–1075 (2002). https://doi.org/10.1038/nn944 Download citation * Received: 15 July 2002 * Accepted: 12 September 2002 * Published: 28 October 2002 * Issue Date: November 2002

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