Temporal structure in neuronal activity during working memory in macaque parietal cortex

ABSTRACT Many cortical structures have elevated firing rates during working memory, but it is not known how the activity is maintained. To investigate whether reverberating activity is

important, we studied the temporal structure of local field potential (LFP) activity and spiking from area LIP in two awake macaques during a memory-saccade task. Using spectral analysis, we

found spatially tuned elevated power in the gamma band (25–90 Hz) in LFP and spiking activity during the memory period. Spiking and LFP activity were also coherent in the gamma band but not

at lower frequencies. Finally, we decoded LFP activity on a single-trial basis and found that LFP activity in parietal cortex discriminated between preferred and anti-preferred direction

with approximately the same accuracy as the spike rate and predicted the time of a planned movement with better accuracy than the spike rate. This finding could accelerate the development of

a cortical neural prosthesis. Access through your institution Buy or subscribe This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through your

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our FAQs * Contact customer support SIMILAR CONTENT BEING VIEWED BY OTHERS FRONTOTEMPORAL COORDINATION PREDICTS WORKING MEMORY PERFORMANCE AND ITS LOCAL NEURAL SIGNATURES Article Open access

17 February 2021 THETA-PHASE DEPENDENT NEURONAL CODING DURING SEQUENCE LEARNING IN HUMAN SINGLE NEURONS Article Open access 10 August 2021 NEURONAL SELECTIVITY FOR STIMULUS INFORMATION

DETERMINES PREFRONTAL LFP GAMMA POWER REGARDLESS OF TASK EXECUTION Article Open access 11 May 2023 REFERENCES * Fuster, J. _Memory in Cerebral Cortex: An Empirical Approach to Neural

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Recognition and Neural Networks_ (Cambridge University Press, Cambridge, 1996). Book  Google Scholar  Download references ACKNOWLEDGEMENTS This work was supported by the DARPA grant

MDA972-00-1-0029, NIH grants EY05522-21 and MH62528-01, ONR grant N00014-94-0412, the Keck Foundation, the McKnight Foundation, the Sloan-Swartz Foundation, the Center for Neuromorphic

Systems Engineering at Caltech and the Workshop for the Analysis of Neural Data (http://www.vis.caltech.edu/~WAND). AUTHOR INFORMATION Author notes * Partha P. Mitra Present address: Bell

Labs, Lucent Technologies, Murray Hill, 07974, New Jersey, USA * Richard A. Andersen Present address: Division of Biology, Mail Code 216-76, California Institute of Technology, Pasadena,

91125, California, USA * John S. Pezaris Present address: Department of Neurobiology, Harvard Medical School, Boston, Massachusetts, 02115, USA * Maneesh Sahani Present address: Gatsby

Computational Neuroscience Unit, Alexandra House, 17 Queen Square, London, WC1N 3AR, UK AUTHORS AND AFFILIATIONS * Division of Physics, Mathematics & Astronomy, California Institute of

Technology, Pasadena, 91125, California, USA Bijan Pesaran * Computation and Neural Systems Program, California Institute of Technology, Pasadena, 91125, California, USA John S. Pezaris, 

Maneesh Sahani & Richard A. Andersen Authors * Bijan Pesaran View author publications You can also search for this author inPubMed Google Scholar * John S. Pezaris View author

publications You can also search for this author inPubMed Google Scholar * Maneesh Sahani View author publications You can also search for this author inPubMed Google Scholar * Partha P.

Mitra View author publications You can also search for this author inPubMed Google Scholar * Richard A. Andersen View author publications You can also search for this author inPubMed Google

Scholar CORRESPONDING AUTHOR Correspondence to Richard A. Andersen. ETHICS DECLARATIONS COMPETING INTERESTS The authors declare no competing financial interests. SUPPLEMENTARY INFORMATION

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neuronal activity during working memory in macaque parietal cortex. _Nat Neurosci_ 5, 805–811 (2002). https://doi.org/10.1038/nn890 Download citation * Received: 25 January 2002 * Accepted:

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