A synthetic approach to abiogenesis
A synthetic approach to abiogenesis"
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ABSTRACT Synthetic biology seeks to probe fundamental aspects of biological form and function by construction (resynthesis) rather than deconstruction (analysis). Here we discuss how such an
approach could be applied to assemble synthetic quasibiological systems able to replicate and evolve, illuminating universal properties of life and the search for its origins. Access
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REFERENCES * Woese, C. _Proc. Natl. Acad. Sci. USA_ 95, 6854–6859 (1998). Article CAS Google Scholar * Davies, P.C. _Philos. Trans. A Math. Phys. Eng. Sci._ 369, 624–632 (2011). Article
CAS Google Scholar * Paddon, C.J. et al. _Nature_ 496, 528–532 (2013). Article CAS Google Scholar * Leisner, M., Bleris, L., Lohmueller, J., Xie, Z. & Benenson, Y. _Nat.
Nanotechnol._ 5, 666–670 (2010). Article CAS Google Scholar * Gibson, D.G. et al. _Science_ 329, 52–56 (2010). CAS Google Scholar * Greiss, S. & Chin, J.W. _J. Am. Chem. Soc._ 133,
14196–14199 (2011). Article CAS Google Scholar * Prescher, J.A., Dube, D.H. & Bertozzi, C.R. _Nature_ 430, 873–877 (2004). Article CAS Google Scholar * Marlière, P. et al. _Angew.
Chem. Int. Ed. Engl._ 50, 7109–7114 (2011). Article Google Scholar * Neumann, H., Wang, K., Davis, L., Garcia-Alai, M. & Chin, J.W. _Nature_ 464, 441–444 (2010). Article CAS Google
Scholar * Lajoie, M.J. et al. _Science_ 342, 357–360 (2013). Article CAS Google Scholar * Hirao, I., Kimoto, M. & Yamashige, R. _Acc. Chem. Res._ 45, 2055–2065 (2012). Article CAS
Google Scholar * Rackham, O. & Chin, J.W. _Nat. Chem. Biol._ 1, 159–166 (2005). Article CAS Google Scholar * Noireaux, V., Maeda, Y.T. & Libchaber, A. _Proc. Natl. Acad. Sci.
USA_ 108, 3473–3480 (2011). Article CAS Google Scholar * Kurihara, K. et al. _Nat. Chem._ 3, 775–781 (2011). Article CAS Google Scholar * Nourian, Z., Roelofsen, W. & Danelon, C.
_Angew. Chem. Int. Ed. Engl._ 51, 3114–3118 (2012). Article CAS Google Scholar * Stano, P., D'Aguanno, E., Bolz, J., Fahr, A. & Luisi, P.L. _Angew. Chem. Int. Ed. Engl._ 52,
13397–13400 (2013). Article CAS Google Scholar * Forster, A.C. & Church, G.M. _Mol. Syst. Biol._ 2, 45 (2006). Article Google Scholar * Benner, S.A., Ricardo, A. & Carrigan,
M.A. _Curr. Opin. Chem. Biol._ 8, 672–689 (2004). Article CAS Google Scholar * Budin, I. & Szostak, J.W. _Annu. Rev. Biophys._ 39, 245–263 (2010). Article CAS Google Scholar *
Szostak, J.W., Bartel, D.P. & Luisi, P.L. _Nature_ 409, 387–390 (2001). Article CAS Google Scholar * Mercier, R., Kawai, Y. & Errington, J. _Cell_ 152, 997–1007 (2013). Article
CAS Google Scholar * Lincoln, T.A. & Joyce, G.F. _Science_ 323, 1229–1232 (2009). THE FIRST DEMONSTRATION OF AUTONOMOUS AND EXPONENTIAL RNA SELF-COPYING. Article CAS Google Scholar
* Vaidya, N. et al. _Nature_ 491, 72–77 (2012). Article CAS Google Scholar * Johnston, W.K., Unrau, P.J., Lawrence, M.S., Glasner, M.E. & Bartel, D.P. _Science_ 292, 1319–1325 (2001).
THE FIRST DEMONSTRATION OF A GENERAL RNA-CATALYZED TEMPLATED REPLICATION ACTIVITY. Article CAS Google Scholar * Wochner, A., Attwater, J., Coulson, A. & Holliger, P. _Science_ 332,
209–212 (2011). Article CAS Google Scholar * Attwater, J., Wochner, A. & Holliger, P. _Nat. Chem._ 5, 1011–1018 (2013). AN RNA POLYMERASE RIBOZYME THAT CAN SYNTHESIZE RNAS LONGER THAN
ITSELF. Article CAS Google Scholar * Ninio, J. & Orgel, L.E. _J. Mol. Evol._ 12, 91–99 (1978). Article CAS Google Scholar * Zhang, S., Blain, J.C., Zielinska, D., Gryaznov, S.M.
& Szostak, J.W. _Proc. Natl. Acad. Sci. USA_ 110, 17732–17737 (2013). Article CAS Google Scholar * Deck, C., Jauker, M. & Richert, C. _Nat. Chem._ 3, 603–608 (2011). Article CAS
Google Scholar * Adamala, K. & Szostak, J.W. _Science_ 342, 1098–1100 (2013). TEMPLATED RNA SYNTHESIS WITHIN A PROTOCELL FACILITATED BY CITRATE. Article CAS Google Scholar *
Szostak, J.W. _J. Syst. Chem._ 3, 2 (2012). Article CAS Google Scholar * Zhu, T.F. & Szostak, J.W. _J. Am. Chem. Soc._ 131, 5705–5713 (2009). Article CAS Google Scholar * Szostak,
J.W. _Philos. Trans. R. Soc. Lond. B Biol. Sci._ 366, 2894–2901 (2011). Article CAS Google Scholar * Bowler, F.R. et al. _Nat. Chem._ 5, 383–389 (2013). Article CAS Google Scholar *
Engelhart, A.E., Powner, M.W. & Szostak, J.W. _Nat. Chem._ 5, 390–394 (2013). Article CAS Google Scholar * Powner, M.W., Gerland, B. & Sutherland, J.D. _Nature_ 459, 239–242
(2009). A PREBIOTIC SYNTHESIS OF THE PYRIMIDINE RIBONUCLEOTIDES, PROVIDING KEY BUILDING BLOCKS FOR THE RNA WORLD. Article CAS Google Scholar * Mansy, S.S. & Szostak, J.W. _Proc. Natl.
Acad. Sci. USA_ 105, 13351–13355 (2008). Article CAS Google Scholar * Moretti, J.E. & Müller, U.F. _Nucleic Acids Res._ 10.1093/nar/gkt1405 (21 January 2014). * Ichihashi, N. et al.
_Nat. Commun._ 4, 2494 (2013). Article Google Scholar * Baaske, P. et al. _Proc. Natl. Acad. Sci. USA_ 104, 9346–9351 (2007). Article CAS Google Scholar * Attwater, J., Wochner, A.,
Pinheiro, V.B., Coulson, A. & Holliger, P. _Nat. Commun._ 1, 76 (2010). Article Google Scholar * Koga, S., Williams, D.S., Perriman, A.W. & Mann, S. _Nat. Chem._ 3, 720–724 (2011).
Article CAS Google Scholar * Kim, G.H., Klotchkova, T.A. & Kang, Y.M. _J. Cell Sci._ 114, 2009–2014 (2001). CAS PubMed Google Scholar * Rasmussen, S. et al. _Science_ 303, 963–965
(2004). Article CAS Google Scholar * Cooper, G.J. et al. _Angew. Chem. Int. Ed. Engl._ 50, 10373–10376 (2011). Article CAS Google Scholar * Pinheiro, V.B. et al. _Science_ 336,
341–344 (2012). Article CAS Google Scholar * Szathmáry, E. _Nat. Rev. Genet._ 4, 995–1001 (2003). Article Google Scholar * Attwater, J. et al. _Chem. Sci._ 4, 2804–2814 (2013). Article
CAS Google Scholar * Ameta, S., Winz, M.L., Previti, C. & Jäschke, A. _Nucleic Acids Res._ 42, 1303–1310 (2014). Article CAS Google Scholar * Jiménez, J.I., Xulvi-Brunet, R.,
Campbell, G.W., Turk-MacLeod, R. & Chen, I.A. _Proc. Natl. Acad. Sci. USA_ 110, 14984–14989 (2013). Article Google Scholar Download references ACKNOWLEDGEMENTS This work was supported
by a Homerton College, Cambridge, Junior Research Fellowship (J.A.) and by the Medical Research Council (programme number U105178804). AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Philipp
Holliger and James Attwater are at the Medical Research Council Laboratory of Molecular Biology, Cambridge, UK., James Attwater & Philipp Holliger Authors * James Attwater View author
publications You can also search for this author inPubMed Google Scholar * Philipp Holliger View author publications You can also search for this author inPubMed Google Scholar CORRESPONDING
AUTHOR Correspondence to Philipp Holliger. ETHICS DECLARATIONS COMPETING INTERESTS The authors declare no competing financial interests. RIGHTS AND PERMISSIONS Reprints and permissions
ABOUT THIS ARTICLE CITE THIS ARTICLE Attwater, J., Holliger, P. A synthetic approach to abiogenesis. _Nat Methods_ 11, 495–498 (2014). https://doi.org/10.1038/nmeth.2893 Download citation *
Published: 29 April 2014 * Issue Date: May 2014 * DOI: https://doi.org/10.1038/nmeth.2893 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get
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