Charged for success | Nature Materials

DNA-complexated cationic polymers with reduced charge density, high molecular weight and increased hydrophobicity show a lack of detectable cytotoxicity and efficiently deliver the

apoptosis-inducing TRAIL gene to transplanted tumours in mice. Access through your institution Buy or subscribe This is a preview of subscription content, access via your institution ACCESS

OPTIONS Access through your institution Subscribe to this journal Receive 12 print issues and online access $259.00 per year only $21.58 per issue Learn more Buy this article * Purchase on

SpringerLink * Instant access to full article PDF Buy now Prices may be subject to local taxes which are calculated during checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn about

institutional subscriptions * Read our FAQs * Contact customer support REFERENCES * Edelstein, M. L. et al. _J. Gene Med._ 9, 833–842 (2007). Article  Google Scholar  * Li, S. D. et al. _J.

Control. Release_ 123, 181–183 (2007). Article  CAS  Google Scholar  * Mastrobattista, E. et al. _Nature Rev. Drug Discov._ 5, 115–121 (2006). Article  Google Scholar  * Mintzer M. A. et al.

_Chem. Rev._ 109, 259–302 (2009). Article  CAS  Google Scholar  * Zhou, J. et al. _Nature Mater._ 11, 82–90 (2012). Article  CAS  Google Scholar  * Kurisawa, M., Yokoyama, M. & Okano,

T. _J. Control. Release_ 68, 1–8 (2000). Article  CAS  Google Scholar  * Van Gaal E. V. B. et al. _J. Control. Release_ 154, 218–232 (2011). Article  CAS  Google Scholar  Download references

AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Enrico Mastrobattista and Wim E. Hennink are in the Department of Pharmaceutics, Utrecht University, Universiteitsweg 99, 3584 CG Utrecht, The

Netherlands, Enrico Mastrobattista & Wim E. Hennink Authors * Enrico Mastrobattista View author publications You can also search for this author inPubMed Google Scholar * Wim E. Hennink

View author publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHORS Correspondence to Enrico Mastrobattista or Wim E. Hennink. RIGHTS AND PERMISSIONS

Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Mastrobattista, E., Hennink, W. Charged for success. _Nature Mater_ 11, 10–12 (2012). https://doi.org/10.1038/nmat3209 Download

citation * Published: 15 December 2011 * Issue Date: January 2012 * DOI: https://doi.org/10.1038/nmat3209 SHARE THIS ARTICLE Anyone you share the following link with will be able to read

this content: Get shareable link Sorry, a shareable link is not currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative