Biphasic janus particles with nanoscale anisotropy

ABSTRACT Advances in the field of nanotechnology have fuelled the vision of future devices spawned from tiny functional components that are able to assemble according to a master blueprint1.

In this concept, the controlled distribution of matter or ‘patchiness’2 is important for creating anisotropic building blocks and introduces an extra design parameter — beyond size and

shape3,4. Although the reliable and efficient fabrication of building blocks with controllable material distributions will be of interest for many applications in research and technology,

their synthesis has been addressed only in a few specialized cases5,6. Here we show the design and synthesis of polymer-based particles with two distinct phases. The biphasic geometry of

these Janus particles is induced by the simultaneous electrohydrodynamic jetting7,8,9 of parallel polymer solutions under the influence of an electrical field. The individual phases can be

independently loaded with biomolecules or selectively modified with model ligands, as confirmed by confocal microscopy and transmission electron microscopy. The fact that the spatial

distribution of matter can be controlled at such small length scales will provide access to unknown anisotropic materials. This type of nanocolloid may enable the design of multicomponent

carriers for drug delivery, molecular imaging or guided self-assembly. Access through your institution Buy or subscribe This is a preview of subscription content, access via your institution

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about institutional subscriptions * Read our FAQs * Contact customer support SIMILAR CONTENT BEING VIEWED BY OTHERS JANUS PARTICLES WITH TUNABLE PATCH SYMMETRY AND THEIR ASSEMBLY INTO CHIRAL

COLLOIDAL CLUSTERS Article Open access 21 December 2023 SYNTHESIS AND APPLICATIONS OF ANISOTROPIC NANOPARTICLES WITH PRECISELY DEFINED DIMENSIONS Article 30 November 2020 SELF-REGULATED

CO-ASSEMBLY OF SOFT AND HARD NANOPARTICLES Article Open access 28 September 2021 REFERENCES * Glotzer, S. C. Some assembly required. _Science_ 306, 419–420 (2004). Article  Google Scholar  *

Zhang, Z. L. & Glotzer, S. C. Self-assembly of patchy particles. _Nano Lett._ 4, 1407–1413 (2004). Article  Google Scholar  * Manna, L., Milliron, D. J., Meisel, A., Scher, E. C. &

Alivisatos, A. P. Controlled growth of tetrapod-branched inorganic nanocrystals. _Nature Mater._ 2, 382–385 (2003). Article  Google Scholar  * Malikova, N., Pastoriza-Santos, I., Schierhorn,

M., Kotov, N. A. & Liz-Marzan, L. M. Layer-by-layer assembled mixed spherical and planar gold nanoparticles: control of interparticle interactions. _Langmuir_ 18, 3694–3697 (2002).

Article  Google Scholar  * Hulvat, J. F & Stupp, S. I. Anisotropic properties of conducting polymers prepared by liquid crystal templating. _Adv. Mater._ 16, 589–592 (2004). Article 

Google Scholar  * Teranishi, T., Inoue, Y., Oumi, Y. & Sano, T. Nanoacorns: anisotropically phase-segregated CoPd sulfide nanoparticles. _J. Am. Chem. Soc._ 126, 9914–9915 (2004).

Article  Google Scholar  * Taylor, G. Disintegration of water drops in electric field. _Proc. R. Soc. Lond. A_ 280, 383–397 (1964). Article  Google Scholar  * Zeleny, J. On the conditions of

instability of electrified drops, with applications to the electrical discharge from liquid points. _Proc. Camb. Phil. Soc._ 18, 71–83 (1915). Google Scholar  * Dzenis, Y. Material science:

spinning continuous fibres for nanotechnology. _Science_ 304, 1917–1918 (2004). Article  Google Scholar  * Reneker, D. H. & Chun, I. Nanometre diameter fibres of polymer, produced by

electrospinning. _Nanotechnology_ 7, 216–223 (1996). Article  Google Scholar  * Fong, H., Chun, I. & Reneker, D. H. Beaded nanofibres formed during electrospinning. _Polymer_ 40,

4585–4592 (1999). Article  Google Scholar  * Jun, Z., Hou, H., Schaper, A., Wendorff, J. H. & Greiner, A. Poly-L-lactide nanofibres by electrospinning—Influence of solution viscosity and

electrical conductivity on fiber diameter and fiber morphology. _e-Polymers_ 009, 1–9 (2003). Google Scholar  * Zeng, J. et al. Ultrafine fibres electrospun from biodegradable polymers. _J.

Appl. Polym. Sci._ 89, 1085–1092 (2003). Article  Google Scholar  * Sanders, E. H., Kloefkorn, R., Bowlin, G. L., Simpson, D. G. & Wnek, G. E. Two-phase electrospinning from a single

electrified jet: microencapsulation of aqueous reservoirs in poly(ethylene-co-vinyl acetate) fibres. _Macromolecules_ 36, 3803–3805 (2003). Article  Google Scholar  * Sun, Z., Zussman, E.,

Yarin, A. L., Wendorff, J. H. & Greiner, A. Compound core-shell polymer nanofibres by co-electrospinning. _Adv. Mater._ 15, 1929–1932 (2003). Article  Google Scholar  * Loscertales, I.

G. et al. Electrically forced coaxial nanojets for one-step hollow nanofiber design. _J. Am. Chem. Soc._ 126, 5376–5377 (2004). Article  Google Scholar  * Larsen, G., Velarde-Ortiz, R.,

Minchow, K., Barrero, A. & Loscertales, I. G. A method for making inorganic and hybrid (organic/inorganic) fibres and vesicles with diameters in the submicrometer and micrometer range

via sol-gel chemistry and electrically forced liquid jets. _J. Am. Chem. Soc._ 125, 1154–1155 (2003). Article  Google Scholar  * Loscertales, I. G. et al. Micro/nano encapsulation via

electrified coaxial liquid jets. _Science_ 295, 1695–1698 (2002). Article  Google Scholar  * Berkland, C., Daniel, W., Pack, D. W. & Kim, K. Controlling surface nano-structure using

flow-limited field-injection electrostatic spraying (FFESS) of poly(d,l-lactide-co-glycolide). _Biomaterials_ 25, 5649–5658 (2004). Article  Google Scholar  * Berkland, C., Pollauf, E.,

Pack, D. W. & Kim, K. Uniform double-walled polymer microspheres of controllable shell thickness. _J. Control. Release_ 96, 101–111 (2004). Article  Google Scholar  * Gupta, P. &

Wilkes, G. L. Some investigations on the fiber formation by utilizing a side-by-side bicomponent electrospinning approach. _Polymer_ 44, 6353–6359 (2003). Article  Google Scholar  *

Madhugiri, S., Dalton, A., Gutierrez, J., Ferraris, J. P. & Balkus, K. J. Jr. Electrospun MEH-PPV/SBA-15 composite nanofibres using a dual syringe method. _J. Am. Chem. Soc._ 125,

14531–14538 (2003). Article  Google Scholar  * Barrero, A., Gañán-Calvo, A. M., Dávila, J., Palacio, A. & Gómez-González, E. Low and high Reynolds number flows inside Taylor cones.

_Phys. Rev. E_ 58, 7309–7314 (1998). Article  Google Scholar  * http://www.susqu.edu/facstaff/b/brakke/evolver/evolver.html. * Utada, A. S. et al. Monodisperse double emulsions generated

from a microcapillary device. _Science_ 308, 537–541 (2005). Article  Google Scholar  * Xu, S. et al. Generation of monodisperse particles by using microfluidics: control over size, shape,

and composition. _Angew. Chem. Int. Edn Engl._ 44, 724–728 (2005). Article  Google Scholar  * Hermanson, G. T. _Bioconjugate Techniques_ (Academic, San Diego, 1995). Google Scholar  *

Millman, J. R., Bhatt, K. H., Prevo, B. G. & Velev, O. D. Anisotropic particle synthesis in dielectrophoretically controlled microdroplet reactors. _Nature Mater._ 4, 98–102 (2005).

Article  Google Scholar  * Lu, Y. et al. Asymmetric dimers can be formed by dewetting half-shells of gold deposited on the surfaces of spherical oxide colloids. _J. Am. Chem. Soc._ 125,

12724–12725 (2003). Article  Google Scholar  * Paunov, V. N. & Cayre, O. J. Supraparticles and ‘Janus’ particles fabricated by replication of particle monolayers at liquid surfaces using

a gel trapping technique. _Adv. Mater._ 16, 788–791 (2004). Article  Google Scholar  Download references ACKNOWLEDGEMENTS We thank Solomon, University of Michigan, for use of the confocal

laser scanning microscope and Manke, Wayne State University, for use of the viscometer. D.C.M. acknowledges partial support from the National Science Foundation through grant DMR-0084304.

AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Macromolecular Science and Engineering Center, The University of Michigan, 48109, Ann Arbor, Michigan, USA Kyung-Ho Roh, David C. Martin & 

Joerg Lahann * Department of Materials Science and Engineering, The University of Michigan, 48109, Ann Arbor, Michigan, USA David C. Martin & Joerg Lahann * Department of Chemical

Engineering, The University of Michigan, 48109, Ann Arbor, Michigan, USA Joerg Lahann Authors * Kyung-Ho Roh View author publications You can also search for this author inPubMed Google

Scholar * David C. Martin View author publications You can also search for this author inPubMed Google Scholar * Joerg Lahann View author publications You can also search for this author

inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to Joerg Lahann. ETHICS DECLARATIONS COMPETING INTERESTS The authors declare no competing financial interests. SUPPLEMENTARY

INFORMATION SUPPLEMENTARY INFORMATION Supplementary table 1 (PDF 39 kb) RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Roh, KH., Martin, D. &

Lahann, J. Biphasic Janus particles with nanoscale anisotropy. _Nature Mater_ 4, 759–763 (2005). https://doi.org/10.1038/nmat1486 Download citation * Received: 10 May 2005 * Accepted: 09

August 2005 * Published: 25 September 2005 * Issue Date: 01 October 2005 * DOI: https://doi.org/10.1038/nmat1486 SHARE THIS ARTICLE Anyone you share the following link with will be able to

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