Prion replication—once again blaming the dendritic cell

ABSTRACT The lymphoid system is known to be involved in the propagation and spread of scrapie. However, the identity of the cell type responsible for scrapie replication remains

controversial. A new study provides evidence that the follicular dendritic cells in the spleen are the targets of this infectious form of prion (pages 1308–1312). Access through your

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Prusiner, S.B., Scott, M.R., DeArmond, S.J., & Cohen, F.E. Prion protein biology. _Cell_ 93, 337– 348 (1998). Article  CAS  Google Scholar  * Eklund, C.M., Kennedy, R.C., & Hadlow,

W.J. Pathogenesis of scrapie infection in the mouse. _ J. Infect. Dis._ 117, 15–22 (1967). Article  CAS  Google Scholar  * Fraser, H. & Dickinson, A.G. Pathogenesis of scrapie in the

mouse: the role of spleen. _Nature_ 226, 462 –463 (1970). Article  CAS  Google Scholar  * Kimberlin, R.H., & Walker, C.A. Pathogenesis of mouse scrapie: dynamics of agent replication in

spleen, spinal cord and brain after infection by different route _J. Comp. Path._ 89, 551–562 (1979). Article  CAS  Google Scholar  * Kuroda, Y., Gibbs, C.J. Jr., Amyx, H.L. & Cajdusek,

D.C. Creutzfeldt-Jakob disease in mice: persistent viremia and preferential replication of virus in low-density lymphocytes. _Infect. Immunol._ 41, 154–161 (1983). CAS  Google Scholar  *

Klein, M.A. _ et al._ A crucial role for B cells in neuroinvasive scrapie. _ Nature_ 390, 687–690 ( 1997). Article  CAS  Google Scholar  * Klein. M. A. _ et al._ PrP expression in B

lymphocyte is not required for prion neruoinvasion. _Nat. Med._ 4, 1429–1433 (1998). Article  CAS  Google Scholar  * Raeber, A. J. _ et al._ PrP-dependent association of prions with spleenic

but not circulating lymphocytes of scrapie-infected mice. _EMBO J._ 18, 2702–2706 (1999). Article  CAS  Google Scholar  * Brown, K. L. _ et al._ TSE replication in lymphoid tissues depends

on PrP expressing follicular dendritic cells. _Nat. Med._ 5, 1308–1312 (1999). Article  CAS  Google Scholar  * Van Keulen, L.J., Schreuder, B.E., Vromans, M.E., Langeveld, J.P. & Smits

M.A. Scrapie-associated prion protein in the gastrointestinal tract of sheep with natural scrapie. _J. Comp. Pathol._ 121, 55–63 (1999). Article  CAS  Google Scholar  Download references

AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Division of Neuropathology Institute of Pathology Case Western Reserve University School of Medicine, 10900 Euclid Ave., Cleveland, 44106-4943,

OH Man-Sun Sy & Pierluigi Gambetti Authors * Man-Sun Sy View author publications You can also search for this author inPubMed Google Scholar * Pierluigi Gambetti View author publications

You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Sy, MS., Gambetti, P. Prion replication—once

again blaming the dendritic cell. _Nat Med_ 5, 1235–1237 (1999). https://doi.org/10.1038/15186 Download citation * Issue Date: November 1999 * DOI: https://doi.org/10.1038/15186 SHARE THIS

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