Decoding calcium signals involved in cardiac growth and function

ABSTRACT Calcium is central in the regulation of cardiac contractility, growth and gene expression. Variations in the amplitude, frequency and compartmentalization of calcium signals are

decoded by calcium/calmodulin-dependent enzymes, ion channels and transcription factors. Understanding the circuitry for calcium signaling creates opportunities for pharmacological

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ACKNOWLEDGEMENTS We thank A. Tizenor for assistance with graphics and J. Page for editorial assistance. Work in the authors' laboratory was supported by grants from National Institutes

of Health, the D.W. Reynolds Foundation, the Robert A. Welch Foundation and Myogen Inc. N.F. was supported by a postdoctoral fellowship from Deutsche Forschungsgemeinschaft and T.A.M. is a

Pfizer Fellow of the Life Sciences Research Foundation. AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Molecular Biology, The University of Texas Southwestern Medical Center,

6000 Harry Hines Boulevard, Dallas, 75390-9148, Texas, USA Norbert Frey, Timothy A. McKinsey & Eric N. Olson Authors * Norbert Frey View author publications You can also search for this

author inPubMed Google Scholar * Timothy A. McKinsey View author publications You can also search for this author inPubMed Google Scholar * Eric N. Olson View author publications You can

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Frey, N., McKinsey, T. & Olson, E. Decoding calcium signals involved in cardiac growth and function. _Nat Med_ 6, 1221–1227 (2000). https://doi.org/10.1038/81321 Download citation *

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